A Phase 3b/4 Randomized Double Blind Study Of 5 Mg Of Tofacitinib With And Without Methotrexate In Comparison To Adalimumab With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid Arthritis
A Phase 3b/4 Randomized Double Blind Study Of 5 Mg Of Tofacitinib With And Without Methotrexate In Comparison To Adalimumab With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid Arthritis
To assess the efficacy of tofacitinib monotherapy or tofacitinib with methotrexate as compared to adalimumab with methotrexate. To compare the efficacy of tofacitinib monotherapy compared to tofacitinib combined with methotrexate. To compare effects on all health outcomes measures in the study. To evaluate the safety and tolerability of tofacitinib and adalimumab. To evaluate the safety of the zoster vaccine given prior to the initiation of tofacitinb or adalimumab.
Inclusion Criteria:
Exclusion Criteria:
Fullerton, California 92835, United States
Los Angeles, California 90033, United States
Los Angeles, California 90095, United States
Los Angeles, California 90095, United States
CABA, Buenos Aires C1426AAL, Argentina
Banja Luka, Republika Srpska 78000, Bosnia and Herzegovina
Targovisthe, 7700, Bulgaria
Ostrava- Moravska Ostrava, 702 00, Czechia
Mexico City, Mexico City 11850, Mexico
Mérida, Yucatán 97133, Mexico
San Luis Potosí City, 78213, Mexico
Arequipa, 04020, Peru
Manila, National Capital Region 1000, Philippines
Manila, National Capital Region 1003, Philippines
Petrozavodsk, Karelia Republic 185019, Russia
Moscow, 119991, Russia
Orenburg, 460018, Russia
Ryazan, 390026, Russia
Samara, 443095, Russia
Smolensk, 214025, Russia
Yaroslavl, 150007, Russia
Johannesburg, Gauteng 2193, South Africa
Parktown, Johannesburg, Gauteng 2193, South Africa
Jung-Gu, Incheon 22332, South Korea
Santiago de Compostela, A Coruna 15706, Spain
Taoyuan County, 33305, Taiwan
Bangkok, 10400, Thailand
Samsun, 55139, Turkey (Türkiye)