Pharmacokinetic and Pharmacodynamic Study of Lenograstim for Hematopoietic Stem Cell Mobilization

Pharmacokinetic and Pharmacodynamic Study of Lenograstim for Hematopoietic Stem Cell Mobilization in Patients With Multiple Myeloma

Twenty four patients with multiple myeloma will be randomized to either AM group (administration of lenograstim at 8 am) or PM group (administration of lenograstim at 6 am ). Apheresis of hematopoietic stem cell will start at 10 am on D5 in AM group and at 8 am on D4 in PM group, respectively. Pharmacokinetic data of lenograstim will be correlated with pharmacodynamic data of CD34+ cell count, absolute neutrophil cell count and hematopoeitic progenitor cell count. In addition, the yield of stem cell collection between two arms will be analyzed.

Inclusion Criteria:

• age: above 17 years, below 65 years old
• informed consent
• ECOG 0-1
• autologous stem cell transplant candidate among patients with multiple myeloma

Exclusion Criteria:

• prior history of hematopoetic stem cell transplantation
• history of failure to mobilize hematopoietic stem cells
• history of G-CSF administration within 2 weeks before enrollment to this study