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| ID | Type | Description | Link |
|---|---|---|---|
| 1R03DA035347-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this study is to determine how fast caffeine gets into your body with a product called Aeroshotâ„¢. Aeroshotâ„¢ is a lipstick sized device that you slide open and then put your mouth over the opening and inhale. A fine powder containing 100 mg of caffeine is deposited on your tongue and the inside of your mouth. Caffeine will be absorbed through the membranes in your mouth or swallowed and then absorbed in your stomach. We will compare the absorption of caffeine after using the Aeroshotâ„¢ with the absorption after drinking an energy drink by taking 15 blood samples over 8 hours and measuring the caffeine levels in your blood. You will also be asked to fill out some scales to measure the effects you feel after the caffeine dose. We hypothesize that caffeine absorption after inhalation will be faster than after an energy drink.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aeroshot | Active Comparator | A single 100 mg caffeine dose administered using the Aeroshot device. |
|
| Energy Drink | Active Comparator | A single 100 mg caffeine dose administered as an oral solution. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Caffeine | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Caffeine plasma concentration | These are the collection times of blood samples relative to when the caffeine dose was consumed. | 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes and 2, 3, 4, 6, 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Caffeine effects | Subjects will complete seven analog scales to assess the effects that they feel after the caffeine dose. | 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes, and 2, 3, 4, 6, 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular effects | The heart rate and blood pressure will be recorded at the time of each blood collection. | 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes, and 2, 3, 4, 6, 8 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Steven C. Laizure, Pharm.D. | University of Tennessee | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Tennessee Health Science Center | Memphis | Tennessee | 38163 | United States |
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| ID | Term |
|---|---|
| D002110 | Caffeine |
| ID | Term |
|---|---|
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
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| D011687 |
| Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |