A Diagnostic Study of the Advanced Endoscopy to Detect Early Esophageal Cancer

Diagnostic Values of Probe-based Confocal Laser Endomicroscopy (pCLE) and Magnifying Narrow Band Imaging (M-NBI) for Early Neoplasms Detection in Esophageal Lugol'S-voiding Lesions.

This descriptive cross sectional study aims to directly compare the diagnostic capability of the probed-based confocal laser endomicroscopy (pCLE) and the magnifying narrow band imaging (M-NBI) in the Lugol's voiding lesions.

Inclusion Criteria:

• Age over 20 years
• Having histological-confirmed diagnosis of head and neck cancer
• Having no esophageal symptoms

Exclusion Criteria:

• Having index cancer of nasopharynx
• History of esophageal surgery
• Having esophageal stricture or obstruction
• Having esophageal varices
• Known case of esophageal cancer
• Uncorrectable coagulopathy and thrombocytopenia
• Pregnancy
• Thyrotoxicosis
• Creatinine clearance less than 30 ml/min
• Allergy to iodine or fluorescein.