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| ID | Type | Description | Link |
|---|---|---|---|
| MT2014-10C | Other Identifier | Masonic Cancer Center, University of Minnesota |
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Replaced by another study
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This is a study to collect the outcomes of stem cell transplantation for patients with hematologic diseases other than cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Reduced Toxicity Ablative Regimen | Experimental | For use in patients with a matched sibling donor or unrelated UCB donor and DBA patients who are <12 years and/or have mild/moderate iron exposure. |
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| Reduced Intensity Preparative Regimen | Experimental | For use in patients with unrelated donor bone marrow and for DBA patients who are >12 years and/or have significant iron exposure. |
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| Myeloablative Preparative Regimen | Experimental | For use in patients with a matched sibling donor, unrelated umbilical cord blood and in those with severe thalassemia. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Reduced Toxicity Ablative Regimen | Drug |
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| Measure | Description | Time Frame |
|---|---|---|
| incidence of graft failure | 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| overall survival | 6 months, 1 and 2 years | |
| disease free survival | patient no longer needing red blood cell transfusion and/or a hemoglobin S level at that of the donor ( sickle cell disease only) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ashish Gupta, MBBS, MPH | Masonic Cancer Center, University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota Medical Center, Fairview | Minneapolis | Minnesota | 55455 | United States |
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| Reduced Intensity Preparative Regimen | Drug |
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| Myeloablative Preparative Regimen | Drug |
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| 6 months, 1 and 2 years |
| ID | Term |
|---|---|
| D000755 | Anemia, Sickle Cell |
| D017086 | beta-Thalassemia |
| D029503 | Anemia, Diamond-Blackfan |
| D006457 | Hemoglobinuria, Paroxysmal |
| D013915 | Thrombasthenia |
| C537592 | Neutropenia, Severe Congenital, Autosomal Recessive 3 |
| D000081003 | Shwachman-Diamond Syndrome |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D013789 | Thalassemia |
| D029502 | Anemia, Hypoplastic, Congenital |
| D000741 | Anemia, Aplastic |
| D012010 | Red-Cell Aplasia, Pure |
| D000080984 | Congenital Bone Marrow Failure Syndromes |
| D000080983 | Bone Marrow Failure Disorders |
| D001855 | Bone Marrow Diseases |
| D009190 | Myelodysplastic Syndromes |
| D025861 | Blood Coagulation Disorders, Inherited |
| D001778 | Blood Coagulation Disorders |
| D001791 | Blood Platelet Disorders |
| D006474 | Hemorrhagic Disorders |
| D010188 | Exocrine Pancreatic Insufficiency |
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008052 | Lipid Metabolism, Inborn Errors |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D008068 | Lipomatosis |
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