Ketoprofen Lysine Salt as Mouthwash in Acute Phlogosis of the Pharyngeal Cavity Versus Benzidamine Hydrochloride

MISTRAL (Mouthwash In Sore Throat Relief: Antiinflammatory vs. Local Anesthetic Therapy) "Efficacy and Tolerability of Ketoprofen Lysine Salt as a Mouthwash in Acute Phlogosis of the Pharyngeal Cavity; Multicentre, Randomized, Single-blind, Parallel-group Comparison Versus Benzidamine Hydrochloride"

A study to in order to verify any differences between the 2 treatment groups in terms of duration of analgesic effects after the first drug intake and time to remission of symptoms and signs of pharyngitis

Inclusion Criteria:

• Male and female outpatients, aged 18 to 70 years, suffering from acute pharyngitis, pharyngolaryngitis
• Moderately or severely intense pain in the pharyngeal region (score ≥ 70 mm) from the "visual analogue scale" (VAS)
• At least 1 of the 2 inflammation signs (edema and hyperemia) to be moderately or severely intense (score ≥ 2) from the scoring scale from 0 to 3
• Release of written informed consent by the patient

Exclusion Criteria:

• Patients suffering from a microbial infection requiring specific antimicrobial treatment
• Patients who have taken the trial drugs during the week before enrolment
• Patients who have taken corticosteroids or antibiotics during the week before enrolment
• Ascertained or suspected hypersensitivity to trial drugs or to chemically correlated drugs or to other non-steroidal anti-inflammatory drugs or to mouthwashes in general
• Patients who are unable to properly fill in the diary every day as provided for by the protocol
• Ascertained or presumed pregnant or lactating women
• Inclusion in any other clinical trial during the study