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| Name | Class |
|---|---|
| Royal Adelaide Hospital | OTHER |
| University of South Australia | OTHER |
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Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Wingate HIT | Experimental | 7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training. |
|
| Modified HIT | Experimental | 7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training |
|
| No Exercise Control | Active Comparator | 7 days of high-fat overfeeding (50% excess calories) with no supervised exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wingate HIT | Other | 3 sessions of Wingate based High-Intensity Interval Training (6-8 x 15 second "all out" sprints on a cycle ergometer interspersed by 2 minutes recovery) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in glucose metabolism | Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test. | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in plasma levels of cytokines | Change in plasma levels of adiponectin, irisin, sex hormone-binding globulin and c-reactive protein | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in mitochondrial metabolism | Changes in citrate synthase activity, mitochondrial DNA content and protein levels of PGC-1a | 1 week |
| Change in resting energy expenditure | Changes in resting energy expenditure measured by metabolic cart |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Leonie Heilbronn, PhD | University of Adelaide | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Australian Health & Medical Research Institute | Adelaide | South Australia | 5000 | Australia |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Modified HIT | Other | 3 sessions of Modified High-Intensity Interval Training (8 x 60 second sprints at approximately 90-95% VO2 peak on a cycle ergometer interspersed by 60 seconds recovery) |
|
| High-fat overfeeding | Other | 7 days of high-fat overfeeding (50% excess calories) |
|
| 1 week |
| Change in cognitive function | Changes in cognitive function, assessed by a series of computer tasks involving vigilant attention and speed processing. | 1 week |