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| Name | Class |
|---|---|
| Kellogg Company | INDUSTRY |
There is a lot of evidence to suggest that eating a diet rich in cereals such as wheat bran are beneficial in protecting us from diseases such as heart disease, diabetes and cancer. It is still not clear exactly why this happens, but it is likely that the compounds which enter our bodies when we eat such products are responsible. In this study we plan to find out what these compounds are and where they are found. The investigators will do this by asking volunteers to eat a wheat-bran meal and then measuring the compounds that appear in blood, urine and stool samples over the next twenty-four hours. Once the investigators know how much and which compounds are present, we can then find out possible reasons why they are protective, for example by looking to see whether they are anti-inflammatory. We also plan to look at whether if having a diet which contains either a lot of wheat-bran products or very low amounts of these foods effects how they are absorbed by the body.
HYPOTHESIS: Wheat bran from ready-to-eat cereal has unique phytochemical profiles which are metabolized to compounds responsible for high cellular bioactivity imparting important health benefits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Visit A- 120g wheat bran cereals | Other | A morning vist where volunteers consumed 120g of wheat bran cereals with 125ml semi-skimmed milk |
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| Visit B-40g wheat bran cereals | Other | A morning vist where volunteers consumed 40g of wheat bran cereals with 375 ml semi-skimmed milk |
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| Follow up-40g (8days), 120g (1day) wheat bran cereals | Other | Volunteers follow their normal diet but they were asked to consume 40g wheat bran cereals with 125 ml semi-skimmed milk for eight days and on day nine 120g wheat bran cereals with 375ml semi-skimmed milk |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Visit A high wheat bran | Other |
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| Visit B normal wheat bran |
| Measure | Description | Time Frame |
|---|---|---|
| Human bioavailability of benzoic acids and derivatives from wheat bran cereals | The analysis of the benzoic acid and derivatives metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24 h |
| Human bioavailability of cinnamic acids and derivatives from wheat bran cereals | The analysis of the cinnamic acids and derivatives metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24h |
| Human bioavailability of phenylpropanoid dimers from wheat bran cereals | The analysis of the phenylpropanoid dimers metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24h |
| Human bioavailability of phenyl propionic acids from wheat bran cereals | The analysis of the phenyl propionic acids metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24h |
| Bioavailability of benzaldehydes from wheat bran | The analysis of the benzaldehydes metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24h |
| Human bioavailability of acetophenones from wheat bran cereals | The analysis of the acetophenones metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wendy R Russell, PhD | Rowett Institute of Nutrition and Health, University of Aberdeen | Principal Investigator |
| Baukje de Roos, PhD | Rowett Institute of Nutrition and Health, University of Aberdeen | Principal Investigator |
| Garry Duthie, Professor | Rowett Institute of Nutrition and Health, University of Aberdeen | Principal Investigator |
| Jolene McMonagle, PhD | Kellogg Company | Principal Investigator |
| Reg Fletcher, PhD | Kellogg Company | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rowett Institute of Nutrition and Health, University of Aberdeen | Aberdeen | Aberdeenshire | AB21 9SB | United Kingdom |
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| Other |
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| Follow up normal (8days) and high (1day) bran consumption | Other |
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| over 24h |
| Human bioavailability of lignans from wheat bran cereals | The analysis of the lignans metabolites in blood, urine, faecal samples after consumption of 40g and 120g wheat bran cereals, over 24 h period (change from baseline time 0h). | over 24 h |
| Short chain fatty acids profile after wheat bran consumption (acute) | Short chain fatty acids profile in faecal samples at 0h (baseline) and 24h after wheat bran consumption (40g and 120g). | 24 h |
| Short chain fatty acids profile after wheat bran consumption (chronic) | Short chain fatty acids profile in in faecal samples at day 0 (baseline), day 5 (during 7 days consumption of 40g wheat bran cereals/day) and day 10 (after 120g wheat bran cereals consumption on day 9). | 9 days |