This was a prospective, case-control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVB.

Inclusion Criteria:

• pathologic myopia, defined as spherical equivalent >6 diopters and axial length >26 mm
• posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent);
• fluorescein angiography, indocyanine green angiography and optical coherence tomography detection of the subfoveal or juxtafoveal choroidal neovascularization
• clear ocular media;

Exclusion Criteria:

• previous treatment for choroidal neovascularization, including the previous intravitreal drug injection or PDT
• presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion
• history of recent myocardial infarction or other thromboembolic events
• ongoing uncontrolled hypertension or glaucoma
• refractive media opacities
• previous eye surgery

Patients with myopic Choroidal Neovascularization treated with intravitreal ranibizumab at the Medical Retina Department, University of Molise, Campobasso, Italy