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To explore the application of target controlled infusion of etomidate combined with propofol in the maintenance of anesthesia during brain surgeries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | During maintenance of anesthesia, etomidate was give by target controlled infusion, the effect-site concentration is 0.3 to 0.6 micrograms/ml to keep bispectral index between 40 to 60. |
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| Group B | Experimental | During maintenance of anesthesia, Propofol was give by target controlled infusion, the effect-site concentration is 2 to 4 micrograms/ml to keep bispectral index between 40 to 60. |
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| Group C | Experimental | During maintenance of anesthesia, etomidate will be given by target controlled infusion for 2 h first, and then propofol will be given by target controlled infusion, the effect-site concentration is 0.3 to 0.6 micrograms/ml and 2 to 4 micrograms/ml, respectively. Bispectral index should be kept between 40 to 60. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| propofol | Drug |
| ||
| etomidate |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Heart rate should be recorded before induction, 1 min, 5 min, 20 min after intubation, at the time of skin incision, skull drilling, incision of dura matter, during intracranial operation, suture of dura matter and skin. | Baseline to the end of the operation, expected to be about 6 h |
| Blood pressure | Blood pressure should be recorded before induction, 1 min, 5 min, 20 min after intubation, at the time of skin incision, skull drilling, incision of dura matter, during intracranial operation, suture of dura matter and skin. | Baseline to the end of the operation, expected to be about 6 h |
| Concentration of cortisol | Concentration of cortisol should be recorded before induction, 30 min, 1 h, 2 h after intubation, and immediately when the operation is over. | from baseline to the end of the operation, expected to be about 6 h |
| Measure | Description | Time Frame |
|---|---|---|
| Use of vasoactive agent | The name and dose of the vasoactive agents used from the beginning of induction to the end of operation. | from the beginning of induction to the end of the operation, expected to be about 6 h |
| The time from stop of remifentanil to awake |
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Inclusion Criteria:
Exclusion Criteria:
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| The time from stop of remifentanil to awake, expected to no more than 15 min |
| Severity of agitation | Within 24 h after the operation |
| Postoperative nausea and vomiting | Within 24 h after the operation |
| Dose of etomidate and propofol | From the beginning of induction to the end of the operation, expected to be about 6 h |
| Intraoperative awareness | From the beginning of induction to the end of the operation, expected to be about 6 h |
| Expense of anesthetics | From the beginning of induction to the end of the operation, expected to be about 6 h |
| Allergic reaction | From beginning of induction to 24 h after the operation |
| ID | Term |
|---|---|
| D015742 | Propofol |
| D005045 | Etomidate |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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