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The main objective is to evaluate the interest of the repeated measurement of procalcitonin in patients with pulmonary infection to reduce the duration of antibiotic therapy in comparison with a conventional clinical strategy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Procalcitonine | Experimental | every 2 days, they will receive the dose of PCT and decide to stop antibiotic treatment according to the algorithm 2. They will notify the results of clinical evaluations in the electronics and all adverse event report forms. |
|
| contrôle | No Intervention | Only clinical reassessments will be conducted and documented. Data on antibiotic will be listed and all adverse events. Data on the PCT from D2 to D4, D6, D8 and D15 output or will not be available to the prescriber. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| procalcitonine | Other | The recommendations will be based on the level of PCT: 4 levels of advice will be given:
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of antibiotic therapy | Success of antibiotic therapy within 45 days of inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gaetan Gavazzi | University Clinic of Geriatrics Medicine, Division of Medicine multidisciplinary CHU de Grenoble, | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Grenoble | Grenoble | Auvergne-Rhône-Alpes | 38000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| 15800305 |
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| Background |
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| 36517740 | Derived | Gavazzi G, Drevet S, Debray M, Bosson JL, Tidadini F, Paccalin M, de Wazieres B, Celarier T, Bonnefoy M, Vitrat V. Procalcitonin to reduce exposure to antibiotics and individualise treatment in hospitalised old patients with pneumonia: a randomised study. BMC Geriatr. 2022 Dec 14;22(1):965. doi: 10.1186/s12877-022-03658-4. |