Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
this study aim to investigate the:
Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention.
The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known.
To date, few published studies have examined the association between the polymorphism AGT M235T * and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acute heart failure (AHF) | patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data. | ||
| Non acute heart failure (NAHF) | patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| mortality RAAS | the association between RAAS genes polymorphisms and mortality at one year average | one year |
| Measure | Description | Time Frame |
|---|---|---|
| association between RAAS polymorphism and AHF | the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the RAAS genes polymorphism is studied at patient admission for acute dyspnea. | at admission (an average of 1 day) |
| association between MMP polymorphism and AHF |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Acute onset dyspnea patients
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Nouira Samir, Professor | University of Monastir | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nouira Samir | Monastir | Emergency Department Monastir, Tunisia 5000 | 5000 | Tunisia |
Not provided
| Label | URL |
|---|---|
| official website | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
arterial blood samples collected in EDTA tubes and stored in - 20°C envirement for DNA extraction with salting out methods.
the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the MMP genes polymorphism is studied at patient admission for acute dyspnea. |
| at admission (average of 1 day) |