Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure

Study of Polymorphisms of Renin Angiotensin Aldosteron Systemv(RAAS) and Matrice Metallo Protesase (MMPs) in Acute Heart Failure (AHF)

this study aim to investigate the:

• association of RAAS polymorphisms and AHF
• association of MMP 3 and 12 polymorphisms and AHF

Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention.

The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known.

To date, few published studies have examined the association between the polymorphism AGT M235T * and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.

Inclusion Criteria:

• aged more than 18 year old.
• acute non traumatic dyspnea .

Exclusion Criteria:

• ECG diagnostic for acute myocardial infarction or ischemic chest pain within the prior 24 hours
• a history of a heart transplant, pericardial effusion, chest wall deformity suspected of causing dyspnea
• coma, shock,MV,vasopressor drugs
• arrhythmia serious and sustained,
• pace maker
• severe mitral valve disease,