Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy

Effects of Gut Microflora on the Immune and Nutritional Status of CRC Patients After Chemotherapy

Probiotics modulate the gut microflora and immune status in CRC,which can reduce the side effects of chemotherapy such as diarrhea,infection,neutropenia etc.

Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications; Probiotics may restore the intestinal immunity, mucosal barrier, and nutrient absorption.The adverse effects of chemotherapy and the malnutrition status may be relieved via probiotic administration.

Inclusion Criteria:

• Patients scheduled for chemotherapy after radical resection of colorectal cancer

Exclusion Criteria:

• Palliative resection of colorectal cancer
• Antibiotic,probiotic or prebiotic usage within 1months
• Other malignancy
• History of other abdominal surgery
• Coagulopathy or bleeding disorders
• Pregnant or breast-feeding(for females)
• Impaired liver or renal function