Exercise therapy increase functional capacity improving the morbidity and mortality of patients with cardiovascular disease. Moderate continuous training is the best established training modality for this patients. However, a body of evidence has begun to emerge demonstrating that high intensity interval training obtained better results in terms of morbidity and mortality.

The purpose of this randomized clinical trial was to determine the effect of two types of exercise training: moderate continuous training vs high interval training on functional capacity and quality of life as well as verify the safety in its application.

We included 72 patients with coronary artery disease by assigning one of the training modality for 8 weeks. We analyzed cyclo-ergo-spirometry data, aspect related to quality of life as well as a record of adverse events.

Inclusion Criteria:

• Coronary heart Disease, with functional class II-III according to New York Heart Association classification system.
• At least 4 weeks from acute cardiac event, percutaneous or surgery revascularization.
• Optimized medical treatment in adequate doses ( betablockers, ACE inhibitors, ARA II, statins and antiplatelet drugs)
• Age > 18 years old.
• Willing to participate and sign an informed consent form

Exclusion Criteria:

• Residual ischemia waiting for revascularization.
• Any cardiac event for the last 4 weeks
• Abnormal Ergometry with hemodynamic or clinically significant arrhythmias during the procedure.
• History of severe ventricular arrhythmia
• Uncontrolled glycaemia or blood pressure
• Moderate to severe Chronic Pulmonary Obstructive Disease
• Osteomuscular and/or mental disorder that hampers an adequate adherence to the intervention program
• Other vascular diseases: rheumatologic/ autoimmune disorders, thrombopathies, hemophilia.
• Active oncologic disease.
• Treatment with corticosteroids.