Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy

Remote Ischemia Precondition for Hepatic Protection in Patients Undergoing Hepatectomy: A Single-center Randomized Controlled Trial

Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.

Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.

Inclusion Criteria:

• No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade
• Selective hepatectomy, one time hepatic portal occlusion
• Child-Pugh A

Exclusion Criteria:

• Peripheral vessels diseases
• Not the same surgical procedure as expected
• Administered anti-inflammatory drugs as glucocorticoid etc
• Diagnosed of diabetes
• History of liver surgery
• History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy
• Refuse to join the research
• Patients with psychopathy
• Acute infection need antibiotic therapy
• Hepatic artery or portal vein embolism