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Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.
Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remote ischemia precondition | Experimental | patients in this arm accepted RIPC procedure after induction of anesthesia |
|
| None remote ischemia precondition | Experimental | patients in this arm didn't accept RIPC procedure after induction of anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemia precondition | Other | Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff placed on the right upper arm served as RIPC stimulus. |
|
| Measure | Description | Time Frame |
|---|---|---|
| survival rate | 30 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| alanine aminotransferase (ALT) level in patients' blood | Examine the patients's blood sample for ALT level at 1 day postoperatively | 1 day postoperatively |
| aspartic transaminase (AST) level in patients' blood |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Weifeng Yu, professor | Contact | 86-10-81875231 | ywf808@sohu.com |
| Name | Affiliation | Role |
|---|---|---|
| Weifeng Yu, professor | Eastern Hepatobiliary Surgery Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eastern Hepatobiliary Surgery Hospital | Shanghai | Shanghai Municipality | 200438 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15023554 | Background | Kin H, Zhao ZQ, Sun HY, Wang NP, Corvera JS, Halkos ME, Kerendi F, Guyton RA, Vinten-Johansen J. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res. 2004 Apr 1;62(1):74-85. doi: 10.1016/j.cardiores.2004.01.006. | |
| 1595841 | Background |
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| ID | Term |
|---|---|
| D008113 | Liver Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
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| None remote ischemia precondition | Other | Placed an uninflated cuff on the right upper arm for 30 min. |
|
Examine the patients's blood sample for AST level at 1 day postoperatively
| 1 day postoperatively |
| alanine aminotransferase (ALT) level in patients' blood | Examine the patients's blood sample for ALT level at 3 days postoperatively | 3 days postoperatively |
| aspartic transaminase (AST) level in patients' blood | Examine the patients's blood sample for AST level at 3 days postoperatively | 3 days postoperatively |
| alanine aminotransferase (ALT) level in patients' blood | Examine the patients's blood sample for ALT level at 7 days postoperatively | 7 days postoperatively |
| aspartic transaminase (AST) level in patients' blood | Examine the patients's blood sample for AST level at 7 days postoperatively | 7 days postoperatively |
| complications | Number of participants with adverse events within 30 days postoperatively | 30 days postoperatively |
| Huguet C, Addario-Chieco P, Gavelli A, Arrigo E, Harb J, Clement RR. Technique of hepatic vascular exclusion for extensive liver resection. Am J Surg. 1992 Jun;163(6):602-5. doi: 10.1016/0002-9610(92)90567-b. |
| 2916865 | Background | Delva E, Camus Y, Nordlinger B, Hannoun L, Parc R, Deriaz H, Lienhart A, Huguet C. Vascular occlusions for liver resections. Operative management and tolerance to hepatic ischemia: 142 cases. Ann Surg. 1989 Feb;209(2):211-8. doi: 10.1097/00000658-198902000-00012. |
| 10903590 | Background | Clavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg. 2000 Aug;232(2):155-62. doi: 10.1097/00000658-200008000-00001. |
| 16427543 | Background | Azoulay D, Lucidi V, Andreani P, Maggi U, Sebagh M, Ichai P, Lemoine A, Adam R, Castaing D. Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study. J Am Coll Surg. 2006 Feb;202(2):203-11. doi: 10.1016/j.jamcollsurg.2005.10.021. |
| D008107 |
| Liver Diseases |