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Systematically compare the phenotype and genotype of epithelial odontogenic tumors in children and adults with a clinical, radiographic, pathologic and molecular level.
Either:
establish an observatory of this multidisciplinary tumor establish a tumor bank annotated scale unparalleled testing pathophysiological hypotheses search for prognostic factors.
This is an observational study with retrospective and prospective parts. In retrospective part be included the Patients followed between 1992 and January 2011.
In prospective part will follow the Patients will be included after the starting of study.
There are 2 centers :
Number of patients include in the part retrospective :
Center N°1-300adults Center N°2-90childrens
Number of patients include in the part prospective :
Center N°1- 90 Center N°2- 30
Duration of study is 3 years Duration of inclusion is 32 months Each patient will be followed for 4 months and for further up to 3 years from the first patient included.
We envision a next circuit : obtaining consent, preoperative consultation,surgery, postoperative consultation N°1, postoperative consultation N°2, genetics consultation and monitoring of patients in 6;12;18;24 months from surgery of tumor and limited in 3 years from th 1st patient included.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| epithelial odontogenic tumours |
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| Measure | Description | Time Frame |
|---|---|---|
| Phenotypic and genotypic lines connected to the epithelial odontogenic tumours | In particular, to define the link between the genotype PTCH1, the size of the tumor, its osteolytic character and the predictive factors of recurrence. Data collection at M6, M12, M18, M24 from the surgery date | Month 24 from the surgery date |
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Inclusion criteria
Patient with an osteolytic lesion of the jaws
Patient with epithelial odontogenic tumor:
keratocysts ameloblastoma Pindborg tumor or calcifying (ESWT) Epidermoid (Squamous Odontogenic Tumor SOT) Clear cell (Clear Odontogenic Tumor Cells CCOT)
Patient monitoring in the period 1992 to January 2011 at the Trousseau Hospital (children) or at the Pitie Salpetriere (adult)
Patient aged 5 years or more
Adult patient who had signed informed consent
Holders of parental authority of minor patient were informed and signed consent
Non inclusion criteria
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Patient with an osteolytic lesion of the jaws resulting of an epithelial odontogenic tumor
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| Name | Affiliation | Role |
|---|---|---|
| Blandine Ruhin, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stomatologie et Chirurgie Maxillofaciale - Pitie Salpetriere | Paris | 75013 | France |
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serum bank and tissue bank