The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.

Inclusion Criteria:

• Patients with dental prostheses used for at least 6 months,
• Substantial portion of the oral mucosa covered by dental prosthesis.

Exclusion Criteria:

• acute inflammatory disorders other than denture-related stomatitis, neoplastic disease relapses or chemotherapy courses less than 5 years before the enrolment,
• antibiotics in less than 4 weeks before the enrolment,
• anti-inflammatory drugs (steroids and non-steroidal, excluding aspirin in doses less than 80 mg) in less than 2 months before the enrolment,
• history of myocardial infarction, acute coronary incident or vascular inflammation in 5 weeks or less before the enrolment,
• chronic haematological disorders and immunodeficiencies less than 5 weeks before the enrolment,
• major medication changes less than 5 weeks before the enrolment or during study.

Dental clinic patients wearing dentures