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Hibiscus sabdariffa calyces (HSC) extract is consumed in different parts of the world as a cold or hot drink and is available in the United Kingdom (UK) markets in different forms including tea bags. There is preliminary data that support the hypothesis that HSC extract consumption has beneficial effect on blood vessel health and blood pressure reduction. Hypertension, vascular dysfunction, inflammation and lipid abnormalities are all key modifiable risk factors of cardiovascular diseases (CVD), the leading causes of death throughout the world. In the PHYTOVAS (PHYTOchemicals and VAScular Function) study the effect of the acute consumption a potentially bioactive food extracts: Hibiscus sabdariffa calyces (HSC) compared with a matched control (water) on blood pressure and blood vessels function will be investigated after a high - fat mixed meal. This is with a view to determining the impacts of the extract on postprandial (after meal) blood pressure and other CVD risk factors. Results from the PHYTOVAS study could lead to identification of more dietary approaches that will contribute to CVD risk prevention and management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hibiscus sabdariffa calyces extract as a cold drink | Experimental | Subjects are asked to consume 250 ml of Hibiscus calyces drink after a high fat breakfast |
|
| Water | Placebo Comparator | Subjects are asked to consume 250 ml of water after a high fat breakfast |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hibiscus sabdariffa calyces extract as a cold drink | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in baseline and hourly blood pressure | Baseline, hourly 4 times post baseline and then hourly for twelve hours at night |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Flow Mediated Vasodilation | Baseline, 2 and 4 hours post treatment | |
| Change in blood lipids profile | Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment | |
| Measure | Description | Time Frame |
|---|---|---|
| Change in arterial stiffness measured by Pulse Wave Analysis (PWA) | Baseline, 2 and 4 hours post treatment | |
| Pharmacokinetics of plasma anthocyanins and phenolic acids measured as Area Under the Concentration - Time Curve (AUC 0 - 4 hours for plasma) | Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Julie A. Lovegrove, BSc, PhD, RNutr | University of Reading | Principal Investigator |
| Jeremy P.E. Spencer, B.Sc, PhD | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food and Nutritional Sciences, University of Reading, | Reading | Berkshire | RG6 6AP | United Kingdom |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Change in Inflammatory marker: C - reactive protein (CRP) |
| Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment |
| Change in plasma nitric oxide level | Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment |
| Change in serum total antioxidant capacity | Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment |
| Changes in serum or plasma glucose and insulin levels | Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment |