Risk of Diabetes in Young Turner Syndrome Patients

Beta-Cell Function in Young Turner Syndrome Patients

Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.

The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam

Turner Syndrome Females:

Inclusion Criteria:

• Turner Syndrome confirmed by chromosomal testing
• On standard therapy (growth hormone and or estrogen)

Exclusion Criteria:

• Type 1 or Type 2 diabetes
• Polycystic Ovarian Syndrome
• Pregnancy
• On any medications that alter blood sugar

Healthy Female Controls:

Inclusion Criteria:

• Healthy

Exclusion Criteria:

• Type 1 or Type 2 diabetes
• Polycystic Ovarian Syndrome
• Pregnancy
• On any medications that alter blood sugar