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This study is not feasible to conduct as functional brain imaging capability is inadequate. CIRB acknowledged in June 2016.
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| Name | Class |
|---|---|
| Duke-NUS Graduate Medical School | OTHER |
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Functional magnetic resonance imaging in women with chronic pelvic pain using arterial spin labelling, functional connectivity, diffusion tensor imaging and magnetic resonance spectroscopy.
Multimodal magnetic resonance neuroimaging will be utilised. Arterial spin labelling is tightly coupled with cerebral metabolism and can be used as a marker of neural activity. Resting state magnetic resonance imaging which measures synchronous activity across the brain, allows detection of functional connectivity of intrinsic brain network. Diffusion tensor imaging detects the anisotropic water diffusion in axonal fibres can provide information on connectivity and fibre tracts. Magnetic resonance spectroscopy would enable the levels of neurotransmitter to be elucidated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnetic resonance imaging | Experimental | Functional magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance spectroscopy to evaluate women with chronic pelvic pain and/ or endometriosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional magnetic resonance imaging | Other | 3 Tesla magnetic resonance imaging |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with increase in insula anterior cingulate cortex signal on magnetic resonance imaging | Magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance imaging | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects in psychological testing with increased anxiety, depression and pain catastrophizing scores | Anxiety, depression and pain catastrophizing scales used for psychological testing | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ban L Sng, FANZCA | KK Women's and Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KK Women's and Children's Hospital | Singapore | 229899 | Singapore |
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| ID | Term |
|---|---|
| D062788 | Adenomyosis |
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |