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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01315-40 | Registry Identifier | IDRCB |
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Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and auditory modalities in subjects with ASD compared to healthy controls and also, over the course of development (children, adults). In order to achieve this goal, the investigators will use complementary techniques (EEG and MRI-based techniques (fMRI, DTI)).
Autism Spectrum Disorders (ASD) are characterized by major handicap in social interaction and in daily life adaptation. The orienting response towards potentially relevant events involves automatic attentional mechanisms that would be elicited mainly by two classes of biologically important stimulations: novel stimuli and emotional stimuli. The neural basis of emotional and change-related attention in ASD will be explored by investigating brain reactivity in both visual and auditory modalities, during tasks mixing emotional and non emotional stimuli.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Controls |
| ||
| Autism Spectrum Disorders |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI-based techniques | Other | fMRI, DTI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neural responses to neutral and emotional stimuli | ERP (Event-related potential), fMRI and DTI | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Children/ adults with ASD and healthy children/ adults
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| Name | Affiliation | Role |
|---|---|---|
| Frédérique BONNET-BRILHAULT, MD,PhD | Institut National de la Santé Et de la Recherche Médicale, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Tours | 37044 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29736682 | Result | Charpentier J, Kovarski K, Roux S, Houy-Durand E, Saby A, Bonnet-Brilhault F, Latinus M, Gomot M. Brain mechanisms involved in angry prosody change detection in school-age children and adults, revealed by electrophysiology. Cogn Affect Behav Neurosci. 2018 Aug;18(4):748-763. doi: 10.3758/s13415-018-0602-8. | |
| 28194102 | Result |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D056324 | Diffusion Tensor Imaging |
| D005071 | Evoked Potentials |
| ID | Term |
|---|---|
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| EEG | Other | ERP |
|
|
| Kovarski K, Latinus M, Charpentier J, Clery H, Roux S, Houy-Durand E, Saby A, Bonnet-Brilhault F, Batty M, Gomot M. Facial Expression Related vMMN: Disentangling Emotional from Neutral Change Detection. Front Hum Neurosci. 2017 Jan 30;11:18. doi: 10.3389/fnhum.2017.00018. eCollection 2017. |
| 33395999 | Result | Charpentier J, Latinus M, Andersson F, Saby A, Cottier JP, Bonnet-Brilhault F, Houy-Durand E, Gomot M. Brain correlates of emotional prosodic change detection in autism spectrum disorder. Neuroimage Clin. 2020;28:102512. doi: 10.1016/j.nicl.2020.102512. Epub 2020 Nov 27. |
| 33414385 | Result | Kovarski K, Charpentier J, Roux S, Batty M, Houy-Durand E, Gomot M. Emotional visual mismatch negativity: a joint investigation of social and non-social dimensions in adults with autism. Transl Psychiatry. 2021 Jan 5;11(1):10. doi: 10.1038/s41398-020-01133-5. |
| 30227832 | Result | Charpentier J, Kovarski K, Houy-Durand E, Malvy J, Saby A, Bonnet-Brilhault F, Latinus M, Gomot M. Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults. J Neurodev Disord. 2018 Sep 18;10(1):28. doi: 10.1186/s11689-018-9246-9. |
| D038524 |
| Diffusion Magnetic Resonance Imaging |
| D008279 | Magnetic Resonance Imaging |
| D014054 | Tomography |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |