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The aim of this study is to describe, in a real-life context, the impact of an epoetin alpha biosimilar, Retacrit®, on anaemia in patients receiving chemotherapy, according to concomitant iron supplementation.
This is a longitudinal, observational, prospective, multicentre, cohort study, conducted on a representative sample of public and/or private hospital-based oncologists and haematologists practicing in Metropolitan France.
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| Measure | Description | Time Frame |
|---|---|---|
| Impact of an epoetin alpha biosimilar with or without iron supplementation on chemotherapy-induced anemia | The efficiency of epoetin alpha biosimilar will be assessed by the responders'rate according to European Society for Medical Oncology (ESMO) guidelines. This rate will be compared depending on the iron supplementation. The safety will be assessed by the record of adverse effects (serious or not) and treatment discontinuation. | Patients are included at the time of the epoetin alpha biosimilar treatment initiation for chemotherapy-induced anemia and followed up to 12 to 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Characteristics of patients receiving treatment with an epoetin alpha biosimilar, Retacrit®, for chemotherapy induced anaemia | Baseline visit | |
| Procedures for evaluating possible iron deficiency and iron supplementation | At 12 to 16 weeks from baseline or at the end of chemotherapy |
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Inclusion Criteria:
Exclusion Criteria:
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Patients for whom the oncologist decides to initiate epoetin alpha biosimilar treatment (curative or prophylactic) will be asked to participate from treatment initiation (baseline visit) up to 12-16 weeks after inclusion.
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| Name | Affiliation | Role |
|---|---|---|
| Hélène ALBRAND, MD | Hospira, now a wholly owned subsidiary of Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Louis Pasteur | Colmar | Alsace | France | |||
| CH Emile Muller |
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| Impact of iron supplementation on the doses of Retacrit® used, and on treatment duration | At 12 to 16 weeks from baseline or at the end of chemotherapy |
| Experience of patients treated with Retacrit® | At 12 to 16 weeks from baseline or at the end of chemotherapy |
| Mulhouse |
| Alsace |
| France |
| CAC Paul Strauss | Strasbourg | Alsace | France |
| Chu Hopital Civil | Strasbourg | Alsace | France |
| MEDIPOLE | Aix-les-Bains | Auvergne-Rhône-Alpes | France |
| CHRA | Annecy | Auvergne-Rhône-Alpes | France |
| Clinique CONVERT | Bourg-en-Bresse | Auvergne-Rhône-Alpes | France |
| Ch Chambery | Chambéry | Auvergne-Rhône-Alpes | France |
| Chu Grenoble | Grenoble | Auvergne-Rhône-Alpes | France |
| Ch Valence | Valence | Auvergne-Rhône-Alpes | France |
| Chu Rennes | Rennes | Basse Normandie | France |
| CHU SUD | Rennes | Basse Normandie | France |
| Clinique St Laurent | Rennes | Basse Normandie | France |
| Chp St Greg | Saint-Grégoire | Basse Normandie | France |
| Ch St Malo | St-Malo | Basse Normandie | France |
| CHG William MOREY | Chalon S/s | Bourgogne-Franche-Comté | France |
| CHU du BOCAGE | Dijon | Bourgogne-Franche-Comté | France |
| Clinique St Faron | Meaux | Champagne | France |
| Cac Jean Godinot | Reims | Champagne | France |
| Hopital St Quentin | Saint-Quentin | Champagne | France |
| Hopital Troyes | Troyes | Champagne | France |
| Clinique Pasteur | Évreux | Haute Normandie | France |
| CH Jacques Monod | Montivilliers | Haute Normandie | France |
| CHG | Alès | Languedoc | France |
| CHG | Carcassonne | Languedoc | France |
| Chu St Eloi | Montpellier | Languedoc | France |
| CHU Caremeau | Nîmes | Languedoc | France |
| Ch Du Pays D'Aix | Aix-en-Provence | Marseille | France |
| Clinique Rambot | Aix-en-Provence | Marseille | France |
| Ch Duffaut | Avignon | Marseille | France |
| Chu Timone | Marseille | Marseille | France |
| Fondation Saint Joseph | Marseille | Marseille | France |
| Hopital A.Pare | Marseille | Marseille | France |
| IPC | Marseille | Marseille | France |
| Chu Estaing | Clermont | Massif Central | France |
| Chu Gabriel Montpied | Clermont | Massif Central | France |
| Pole Sante Republique | Clermont | Massif Central | France |
| Clinique Vitalia Desertines | Montluçon | Massif Central | France |
| CHR | Roanne | Massif Central | France |
| Icl St Etienne | Saint-Etienne | Massif Central | France |
| CHG Cahors | Cahors | Midi Pyrennees | France |
| CHG St Gaudens | Saint-Gaudens | Midi Pyrennees | France |
| Clinique de l'Ormeau | Tarbes | Midi Pyrennees | France |
| CHU Purpan | Toulouse | Midi Pyrennees | France |
| Clinique Pasteur | Toulouse | Midi Pyrennees | France |
| Inst. Claudius Regaud | Toulouse | Midi Pyrennees | France |
| Clinique des Bonnettes | Arras | Nord | France |
| CH Boulogne-sur-Mer | Boulogne | Nord | France |
| Centre Oscar Lambret | Lille | Nord | France |
| Clinique des Dentellieres | Valenciennes | Nord | France |
| Chi Frejus - St Raphael | Fréjus | Paca | France |
| Clinique Belvédère | Nice | Paca | France |
| CH Sainte Musse | Toulon | Paca | France |
| H.I.A Saint Anne | Toulon | Paca | France |
| Victor Dubos | Argenteuil | Paris Nord | France |
| Clinique Ste Marie | Osny | Paris Nord | France |
| Saint Antoine | Paris | Paris Nord | France |
| Saint Louis | Paris | Paris Nord | France |
| TENON | Paris | Paris Nord | France |
| Hpt Rene Dubos | Pontoise | Paris Nord | France |
| BEAUJON | Clichy | Paris Ouest | France |
| Hopital Mignot | Le Chesnay | Paris Ouest | France |
| Hopital Franco Britannique | Levallois-Perret | Paris Ouest | France |
| Hopital Des Courses | Maisons-Laffitte | Paris Ouest | France |
| HARTMANN | Neuilly/seine | Paris Ouest | France |
| Hopital Foch | Suresnes | Paris Ouest | France |
| Ico Angers | Angers | Pays de la Loire Region | France |
| Ch Le Mans | Le Mans | Pays de la Loire Region | France |
| Victor Hugo | Le Mans | Pays de la Loire Region | France |