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The proposed study seeks to better understand the role of body weight, energy expenditure, and energy intake as mechanisms of body weight gain during detraining following aerobic exercise. It is hypothesized that participants in the higher dose exercise group will have greater body weight gain compared to the lower exercise dose and control group from wk 24 to wk 76 follow-up.
Eligibility criteria include having successfully completed the main E-Mechanic study, be willing to archive blood samples and not being currently enrolled in another study that may effect body, energy intake or energy expenditure. The investigators will measure body weight, waist/hip circumference, blood pressure, body composition, physical activity, questionnaire about appetite/food intake and physical fitness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Living | non exercise healthy living control group | ||
| General Health | Exercise Group (8 KKW) One exercise group will obtain 8KKW (kcal/kg/week) over 3-4 sessions per week, which will result in each session lasting approximately 30 minutes. We will recruit 1 year post study intervention. | ||
| Weight Loss | Exercise Group (20 KKW) Exercise group will obtain 20 KKW, perform in 4-5 sessions per week for approximately 50-70 minutes per session. We will recruit 1 year post study intervention. |
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| Measure | Description | Time Frame |
|---|---|---|
| Body Weight | Fasting body weight | Week 64 - 88 post study randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Energy Expenditure | Energy expenditure is calculated with the Sensewear Armband. | Week 64 - 90 since study randomization |
| Energy Intake | Energy expenditure is calculated with the Sensewear Armband and furthermore, energy intake is calculated by adjusting TDEE for change in body weight following the methods used in doubly labeled water adjustment. |
| Measure | Description | Time Frame |
|---|---|---|
| Circumferences | Waist and hip circumferences | Week 64-88 post study randomization |
| Blood Pressure | Week 64-88 post study randomization | |
Inclusion Criteria:
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Participants that successfully enrolled and completed the E-Mechanic study and are not past 88 weeks study randomization.
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| Name | Affiliation | Role |
|---|---|---|
| John W Apolzan, PhD | PBRC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 5, 2022 | |
| Reset | Aug 22, 2023 | |
| Release | Aug 30, 2023 | |
| Reset | Mar 14, 2024 | |
| Release | May 6, 2024 | |
| Reset | Sep 18, 2024 | |
| Release | Dec 12, 2025 | |
| Reset | Jan 2, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 5, 2022 | Aug 22, 2023 | |||
| Aug 30, 2023 |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D001835 | Body Weight |
| D009765 | Obesity |
| D057185 | Sedentary Behavior |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D050177 | Overweight |
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serum, plasma
| Week 64 - 90 post study randomization |
| Body Composition |
Whole Body Scan GE iDXA (Dual energy x-ray absorptiometry) |
| Week 64 - 88 post study randomization |
| Triglycerides | Week 64 - 88 post study randomization |
| Cholesterol | Total, HDL, and LDL cholesterol | Week 64 - 88 post study randomization |
| Mar 14, 2024 |
| May 6, 2024 | Sep 18, 2024 |
| Dec 12, 2025 | Jan 2, 2026 |
| D044343 |
| Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |