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The folliculitis decalvans (FD) is an orphan disease , common in consultation specialized on scalp. This disease is currently not curable, responsible for significant for patients. The pathophysiology is poorly understood, Staphylococcus aureus (SA) appears to play a role, never previously studied, and the study will attempt to clarify it.
Controversies in the literature on the pathophysiological hypotheses can be summed up as follows :
FD is it an infectious folliculitis where SA (almost always found on the lesions plays a direct role possibly aided by a lack of local immune protection , or is it a pustular inflammatory unknown cause where the SA has no direct role but is a cofactor or a simple germ superinfection.
Our study has plans to bring new evidence to help decide between these two opposite but not mutually exclusive concepts .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| case | Patient with a folliculitis Decalvans |
| |
| control | Control without folliculitis decalvans |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention : case control study | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony) | The primary endpoint is the presence of Staphylococcus Aureus in cutaneous biopsies before any therapy and notably antibiotics. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony) after treatment | 10 weeks | |
| presence of Staphylococcus Aureus in nasal swab (at least one colony) | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with Folliculitis Decalvans
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint-Louis Hospital | Paris | Paris | 75010 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30907453 | Derived | Matard B, Donay JL, Resche-Rigon M, Tristan A, Farhi D, Rousseau C, Mercier-Delarue S, Cavelier-Balloy B, Assouly P, Petit A, Bagot M, Reygagne P. Folliculitis decalvans is characterized by a persistent, abnormal subepidermal microbiota. Exp Dermatol. 2020 Mar;29(3):295-298. doi: 10.1111/exd.13916. Epub 2019 May 15. |
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| ID | Term |
|---|---|
| D013203 | Staphylococcal Infections |
| ID | Term |
|---|---|
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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