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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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This study is investigating whether changes in the shape and size of bodily muscles and spinal cord anatomy can influence recovery rates following a motor vehicle collision (MVC). The objective is to demonstrate that the presence of muscle and spinal cord degeneration and associated muscle weakness is the consequence of a mild MVC-related injury involving the cervical spinal cord.
Whiplash is a condition that consists of patients that display varying degrees of pain and disability. Most patients should expect full-recovery within the first 2-3 months post injury. At the other end of the spectrum is a group of patients (~ 25%) who continue to have moderate-severe pain-related disability in the long-term. Reasons for this transition to chronicity are largely unknown. The situation would benefit if there were radiological findings of the disorder. However, clear and consistent findings of injured tissues on standard radiological exams remain elusive.
As part of this study, the investigators will innovatively investigate measures to 1) quantify the temporal development of widespread muscle degeneration, 2) identify quantifiable markers of altered cervical spinal cord physiology, 3) quantify reductions in central activation and fatigue 4) evaluate potential genetic variants that may be associated with chronic pain after a MVC and 5) determine the mediational influence of psychosocial factors on recovery rates following whiplash injury, as a potential mechanism underlying the transition to chronic pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Procedures | Experimental | RNA/DNA blood sample will be collected. Participant will complete questionnaires, MRI and strength and reflex testing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pedometer | Device |
| ||
| MRI |
| Measure | Description | Time Frame |
|---|---|---|
| MRI to assess the changes in markers of altered cervical spinal cord physiology and muscle degeneration. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Measure | Description | Time Frame |
|---|---|---|
| Neck Disability Index (NDI) Questionnaire | This questionnaire will access the influence of psychosocial factors on recovery rates over a period of time. | <1 week; 2 weeks, 3 months; 1 year of MVC |
| Coping Strategy Questionnaire-C |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| James M Elliott, PhD | Northwestern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwestern University | Chicago | Illinois | 60611 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39972963 | Derived | Smith AC, Laguna JM, Wesselink EO, Scott ZE, Jenkins H, Thornton WA, Wasielewski M, Connor J, Delp S, Chaudhari AS, Parrish TB, Mackey S, Elliott JM, Weber KA 2nd. Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer-Vision Model and Fat-Water MRI. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13735. doi: 10.1002/jcsm.13735. | |
| 37099498 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 25, 2021 | |
| Reset | Jun 17, 2021 | |
| Release | Jul 13, 2021 | |
| Reset | Aug 3, 2021 | |
| Release | May 6, 2024 | |
| Reset | Jun 5, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 25, 2021 | Jun 17, 2021 | |||
| Jul 13, 2021 |
| ID | Term |
|---|---|
| D014911 | Whiplash Injuries |
| D019547 | Neck Pain |
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D019838 | Neck Injuries |
| D014947 | Wounds and Injuries |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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|
This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time.
| < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Pain Management Inventory (PMI) Questionnaire | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Tampa Questionnaire | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks, 3 months; 1 year of MVC |
| Post-traumatic Diagnostic Scale (PDS) Questionnaire | This questionnaire will access the influence and psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Impact of Events Scale Questionnaire | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Center for Epidemiological Studies - Depression Scale Questionnaire | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Hospital Anxiety and Depression Scale Questionnaire | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year of MVC |
| Traumatic Injuries Distress Scale and a Symptom Index | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | < 1 week; 2 weeks; 3 months; 1 year after MVC |
| Prediction of Post-MVC Chronic Axial Pain Assessment | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | Baseline visit |
| Follow-Up Data Collection Form for clinical prediction | This questionnaire will access the influence of psychosocial factors and recovery rates over a period of time. | 2 week; 3 month; 1 year of MVC |
| Pedometer: wear for 2 consecutive weeks | The pedometer will record changes in activity level. | 2 weeks; 3 months after MVC |
| RNA and DNA blood collection | The samples will evaluate potential genetic variants that may be associated with chronic pain after a MVC. | within a week of MVC |
| Strength and reflex testing in the lower leg | This testing will demonstrate changes in central activation and fatigue. | 2 weeks; 3 months; 1 year |
| Callan B, Walton DM, Cleland J, Kolber MJ, Elliott JM. Exploring sex as a moderator of other prognostic variables in whiplash associated disorder: An observational study. PLoS One. 2023 Apr 26;18(4):e0282640. doi: 10.1371/journal.pone.0282640. eCollection 2023. |
| 36958668 | Derived | Elliott JM, Walton DM, Albin SR, Courtney DM, Siegmund GP, Carroll LJ, Weber KA 2nd, Smith AC. Biopsychosocial sequelae and recovery trajectories from whiplash injury following a motor vehicle collision. Spine J. 2023 Jul;23(7):1028-1036. doi: 10.1016/j.spinee.2023.03.005. Epub 2023 Mar 21. |
| 34705736 | Derived | Modarresi S, MacDermid JC, Suh N, Elliott JM, Walton DM. How Is the Probability of Reporting Various Levels of Pain 12 Months After Noncatastrophic Injuries Associated with the Level of Peritraumatic Distress? Clin Orthop Relat Res. 2022 Feb 1;480(2):226-234. doi: 10.1097/CORR.0000000000002024. |
| Aug 3, 2021 |
| May 6, 2024 | Jun 5, 2024 |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |