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It has not been well known about the changes of bone metabolic markers, bone mineral density and other bone-related markers after teriparatide and/or denosumab treatment in Japanese osteoporotic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Denosumab and/or teriparatide treatment | Experimental | Denosumab and/or teriparatide treatment in osteoporotic patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Denosumab treatment in osteoporotic patients | Drug | To examine the effectiveness of denosumab in osteoporotic patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of bone mineral density | Bone mineral density will be examined every 4-6 months to evaluate the suitability of the drug. | every 4-6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of bone turnover markers | Bone turnover markers will be examined every 3-6 months to evaluate the suitability of the drug. | every 3-6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yukio Nakamura, MD, PhD | Contact | +81-263-37-2659 | yxn14@aol.jp |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yukio Nakamura | Recruiting | Matsumoto | Nagano | 3908621 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26666998 | Derived | Nakamura Y, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Taguchi A, Kato H. Changes in serum vitamin D and PTH values using denosumab with or without bisphosphonate pre-treatment in osteoporotic patients: a short-term study. BMC Endocr Disord. 2015 Dec 15;15:81. doi: 10.1186/s12902-015-0077-3. |
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| Teriparatide treatment in osteoporotic patients | Drug | To examine the effectiveness of teriparatide in osteoporotic patients |
|
| Denosumab and teriparatide treatment in osteoporotic patients | Drug | To examine the effectiveness of denosumab and teriparatide in osteoporotic patients |
|
| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000069448 | Denosumab |
| ID | Term |
|---|---|
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
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