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Compromised peripheral tissue oxygenation during surgery may lead to worse patient outcome, mainly due to post-operative infections or heart failure. Insufficient stroke volume and/or cardiac output due to hypovolemia or cardiac defects play a central role in causing poor peripheral tissue oxygenation. In order to assess stroke volume, there are numerous invasive and non-invasive methods available. Up to the present date it is unknown, if these methods may by used interchangeably in patients with severe cardiac defects like aortic stenosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hemodynamic optimisation | |||
| No hemodynamic optimisation |
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| Measure | Description | Time Frame |
|---|---|---|
| Measurement of stroke volume (ml) before TAVI (transcatheter aortic valve implantation) by means of (1) FloTrac, (2) transesophageal doppler echocardiography, (3) pulmonary thermodilution via pulmonary artery catheter | Before Surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks | |
| Measurement of cardiac output (l/min) before TAVI (transcatheter aortic valve implantation) by means of (1) FloTrac, (2) transesophageal doppler echocardiography, (3) pulmonary thermodilution via pulmonary artery catheter | Before Surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of stroke volume (ml) after TAVI (transcatheter aortic valve implantation) by means of (1) FloTrac, (2) transesophageal doppler echocardiography and (3) pulmonary thermodilution via pulmonary artery catheter | After surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks | |
| Accordance of stroke volume and cardiac output measurements assessed by (1) FloTrac, (2) transesophageal doppler echocardiography and (3) pulmonary thermodilution via pulmonary artery catheter AFTER ADMINISTRATION OF FLUID BOLUS |
| Measure | Description | Time Frame |
|---|---|---|
| oxygen delivery (ml) | Before and after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks | |
| image quality of echocardiography | Before and after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
Inclusion Criteria:
Exclusion Criteria:
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Cardiac surgery at a university hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Sander, MD | Contact | +4930450531052 | michael.sander@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Michael Sander, MD | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Universitätsmedizin Berin | Recruiting | Berlin | State of Berlin | 10117 | Germany |
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| Before and after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Accordance of stroke volume and cardiac output measurements assessed by two of the mentioned methods [i.e. (1) FloTrac, (2) transesophageal doppler echocardiography and (3) pulmonary thermodilution via pulmonary artery catheter] | Before and after Surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Measurement of cardiac output (l/min) after TAVI (transcatheter aortic valve implantation) by means of (1) FloTrac, (2) transesophageal doppler echocardiography and (3) pulmonary thermodilution via pulmonary artery catheter | After Surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Length of stay on ICU | participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Cumulative rate of infections | after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| incidence of delirium after surgery | after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| dosage of inotropic medication (mg/d) | after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| length of hospital stay | after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| incidence of stroke | after surgery; participants will be followed for the duration of hospital stay, an expected average of 2 weeks |