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| Name | Class |
|---|---|
| Thoratec Corporation | INDUSTRY |
| National Skeletal Muscle Research Center | UNKNOWN |
| Greater New York Geriatric Cardiology Consortium | UNKNOWN |
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This is an observational study evaluating changes in frailty and associated impairments in older heart failure patients receiving left ventricular assist device therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Older, left ventricular assist device | Older heart failure patients undergoing left ventricular assist device implantation |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in frailty following left ventricular assist device implantation | Frailty will be assess based on the domains initially described by Fried and colleagues: weakness, low physical activity, unintentional weight loss, slowness and exhaustion. Additional frailty measures include the Short Physical Performance Battery (SPPB), as well as gait speed and hand grip strength as single item measures. | Baseline (prior to surgery); 10 days, 1 month, 3 months, and 6 months post-operatively |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle size as measured by ultrasonography | Baseline (prior to surgery); 10 days and 3 months postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function measured by the Montreal Cognitive Assessment | Baseline; 3 and 6 months post-operatively |
Inclusion Criteria:
Exclusion Criteria:
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Consecutive heart failure patients 60 years old or older undergoing left ventricular assist device implantation.
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| Name | Affiliation | Role |
|---|---|---|
| Gordon R Reeves, MD, MPT | Thomas Jefferson University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28940248 | Result | Maurer MS, Horn E, Reyentovich A, Dickson VV, Pinney S, Goldwater D, Goldstein NE, Jimenez O, Teruya S, Goldsmith J, Helmke S, Yuzefpolskaya M, Reeves GR. Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? J Am Geriatr Soc. 2017 Nov;65(11):2383-2390. doi: 10.1111/jgs.15124. Epub 2017 Sep 21. |
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| ID | Term |
|---|---|
| D054143 | Heart Failure, Systolic |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |