In Vitro and In Vivo Comparison Between Intravascular Ultrasound (IVUS) Systems

Simultaneous Acquisition of Intravascular Ultrasound and Near Infrared Spectroscopy Data in the Coronary Artery Study

The purpose of this study is to investigate and compare the images obtained from coronary imaging catheters used in the treatment of coronary blockages both in a clinical setting with patients and in models.

Inclusion Criteria:

• ≥18 years of age
• Scheduled for a coronary angiogram at the Royal Adelaide Hospital.
• Women must be non-lactating or not of childbearing potential (1 year post menopausal or surgically sterilized [total hysterectomy, bilateral tubal ligation, bilateral oophorectomy]).
• Target artery must be >2 mm to accommodate the IVUS catheter.
• IVUS must be clinically indicated or indeterminate angiographic lesion in the artery (40%-70% angiographic stenosis)

Exclusion Criteria:

• Cardiogenic shock
• Contraindications to intracoronary nitroglycerin (hypertrophic obstructive cardiomyopathy; cerebral hemorrhage, head trauma; concomitant sildenafil, tadalafil or vardenafil use)
• Known coronary artery spasm
• Significant bleeding risk (i.e. previous hemorrhagic stroke, active peptic ulcer disease)
• Bleeding diathesis
• Significant renal impairment (patients will be excluded if their calculated creatinine clearance is < 30 mL/min)