Comparative Study of the Therapy of Solar Lentigines With a Q-switched Rubin Laser Versus a Bleaching Cream

Comparative Study Investigating the Therapy of of Solar Lentigines With the Q-switched SINON Rubin 694nm Laser Versus Pigmanorm® Cream

Benign pigmented lesions as solar lentigines are a common finding in Caucasian individuals. Their removal may be requested for aesthetic reasons.

The goal of the study is comparing the efficacy and tolerance of two different therapy modalities established for treating solar lentigines.

The right back of the hand side will be treated with the Q-switched SINON Rubin 694nm Laser, the left back of the hand side with a hydrochinon containing bleaching cream (Pigmanorm® cream).

The investigators estimate that a physical therapy with a Q-switched Rubin laser system is more effective in the removal of solar lentigines than a topical chemical therapy with a hydrochinon containing bleaching cream.

Inclusion Criteria:

• Age ≥ 50
• female patient must be in post-menopause (> 2 years)
• Clinically and dermoscopic confirmed solar lentigines on both sides back of the hands

Exclusion Criteria:

• non melanocytic pigmentation, vitiligo, melanoma and suspicion of melanoma
• intolerance against an ingredience of pigmanorm® cream
• acute inflammation or eczema on back of the hands
• patients with renal disease
• intake of photosensibilisating medication in the past 3 months
• treatment of solar lentigines on back of the hands in the past 6 months
• solarium or sun exposure about 6 weeks before and after treatment
• immunsuppressed patients