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For the chemical lupeol isolated from eggplant, we applied it to one side of face, and applied vehicle control to another side for 8 -weeks. The study was performed in a 8-week, randomized controlled, split face fashion. Investigators evaluated safety and efficacy during baseline, 2 weeks, 4weeks, and 8 weeks after beginning of study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lupeol | Active Comparator | Patients are supposed to apply lupeol on one side of face two times per day for 8 weeks |
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| Control vehicle | Placebo Comparator | Patients are supposed to apply vehicle control to another side of face two times per day for 8 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lupeol | Drug | Patients are supposed to apply lupeol cream to one side of their face two times per day for 8 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acne lesion counts as a measure of efficacy | Both inflammatory & non-inflammatory acne lesions of both of their facial sides | 8 weeks after beginning of applications |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability | Among total patients enrolled in this study, number of patients either experiencing objective adverse events or subjective uncomfortableness were counted | 8 weeks after beggning of applications |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D000152 | Acne Vulgaris |
| ID | Term |
|---|---|
| D017486 | Acneiform Eruptions |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012625 | Sebaceous Gland Diseases |
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| ID | Term |
|---|---|
| C010480 | lupeol |
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| Control vehicle | Drug | Patients are supposed to apply their control vehicle to the other side of their face for 8 weeks |
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