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The purpose of this study is to research the effects of exercise on calories eaten and expended. The investigator expects to find out whether subjects change their eating and activity behaviors when starting an exercise program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Energy Expenditure 300 kcal/day | Experimental | Subjects will be randomly assigned to this group and will exercise energy expenditure of 300 kcal/day. |
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| Exercise Energy Expenditure 600 kcal/day | Experimental | Subjects will be randomly assigned to this group and will exercise energy expenditure of 600 kcal/day. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Energy Expenditure 300 kcal/day | Other |
| ||
| Exercise Energy Expenditure 600 kcal/day |
| Measure | Description | Time Frame |
|---|---|---|
| Negative Energy Balance as assessed by changes in adipose tissue | Whether participants were able to maintain a negative energy balance will be assessed by pre-post changes in stored adipose tissue, as assessed by a dual-energy x-ray absorptiometry scan (DEXA). | End Training (weeks 10-12) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in relative reinforcing value (RRV) of food | RRV of food will be assessed by evaluating the number of responses (mouse button presses) a participant is willing to complete to gain access to food or an alternative sedentary activity. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Average daily calories consumed as assessed by dietary recall |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| James Roemmich, PhD | USDA GFHNRC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USDA Grand Forks Human Nutrition Reserach Center | Grand Forks | North Dakota | 58203 | United States |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D009043 | Motor Activity |
| D001519 | Behavior |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Other |
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On two weekdays and one weekend day, participants will fill out the Automated Self-Administered 24-Hour Dietary Recall (ASA24) to estimate dietary intake (total energy, grams carbohydrates, fat, protein, alcohol). |
| Pre-intervention (week 0) and End Training (weeks 10-12) |
| Pre-post intervention changes in Ghrelin plasma levels | Participants will provide a fasting blood sample collected in ethylenediaminetetraacetic acid (EDTA)-coated and serum tubes. Changes in acylated Ghrelin will be measured via enzyme-linked immunosorbent assay (ELISA). | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Pre-post intervention changes in glucagon-like peptide 1 (GLP-1) plasma levels | Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in GLP-1 concentrations will be measured via ELISA. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Pre-post intervention changes in Ghrelin concentrations | Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in Ghrelin concentrations will be measured via ELISA. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Pre-post intervention changes in irisin concentrations | Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in irisin concentrations will be measured via ELISA. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Pre-post intervention changes in myostatin plasma levels | Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in myostatin levels will be measured via ELISA. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Change in relative reinforcing value (RRV) of physical activity | RRV of physical activity will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to physical activity or a sedentary alternative. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| Change in minutes of sedentary behavior, as assessed by activity tracker | Minutes of sedentary behavior (non-exercise activity) will be assessed by having participants wear an Actigraph accelerometer for 7 days (minimum 10 hours per day) on the right hip. | Pre-intervention (week 0) and End Training (weeks 10-12) |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |