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| ID | Type | Description | Link |
|---|---|---|---|
| POF women | Registry Identifier | Al Azhar U | |
| Stem cell transplantation | Registry Identifier | Al Azhar University |
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Out of 112 high risk patients for Premature Ovarian Failure (POF), diagnosis was established in 10 cases.
ESS cut off point for menstruation and pregnancy was 6.
Out of 112 high risk patients for POF, diagnosis was established in 10 cases. Endometrial fractional biopsy was taken, stained with H&E stain and by immubohistchemical (IH) staining by stem cell marker OCT4. IH expression of stem cell marker OCT4 was evaluated before and after transplantation according to Edessy Stem Cell Score (ESS).
After laparoscopic injection of stem cell sample in the ovaries, participants were followed up monthly for a period of one year by hormonal (FSH, LH and E2), clinical (resuming menstruation), US (folliculometry), histopathological (HP), and IH expression of stem cell (stem cell positivity and scoring according to ESS).
These cases were of ESS 5 and 6.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic Stem Cell Transplantation. | Experimental | Out of 112 high risk patients for POF diagnosis was established in 10 cases. Endometrial fractional biopsy was taken, stained with H&E stain and by IH staining by stem cell marker OCT4. Immunohistochemical expression of stem cell marker OCT4 was evaluated before and after transplantation according to Edessy Stem Cell Scoring (ESS)Laparoscopic injected of stem cell Sample in the ovaries.. Participants were followed up monthly for a period of six months by hormonal (FSH, LH and E2), clinical (resuming menstruation), US (folliculometry), histopathological (HP), and IH expression of stem cell marker OCT4 of the endometrial biopsy (stem cell positivity according to ESS) outcome. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stem Cell | Biological | Out of 112 high risk patients for POF diagnosis was established in 10 cases. Endometrial fractional biopsy was taken, stained with H&E stain and by Immunohistochemical (IH) staining by stem cell marker OCT4. IH expression of stem cell was evaluated before and after transplantation according to Edessy Stem Cell Scoring (ESS). After laparoscopic injection of stem cell sample in the ovaries, participants were followed up monthly for a period of one year by hormonal (FSH, LH and E2), clinical (resuming menstruation and pregnancy), US (folliculometry), histopathological (HP), and IH expression of stem cell (stem cell positivity and scoring according to ESS). |
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy | Hormonal analysis | 104 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Menstruation | Clinical | 104 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Ovulation | Ultrasound | 104 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mahmoud Edessy, Professor | Al-Azhar University | Principal Investigator |
| Hala N Hosni, Professor | Cairo University | Study Chair |
| Yehia Wafa, Professor | Al-Azhar University | Study Chair |
| Yousef Shady, MD | Al-Azhar University | Study Chair |
| Sayed Bakri, MD | Al-Azhar University | Study Chair |
| Medhat Kamel, Msc | Al-Azhar University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Al Azhar University | Cairo | Cairo Governorate | Egypt |
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| ID | Term |
|---|---|
| D016649 | Primary Ovarian Insufficiency |
| ID | Term |
|---|---|
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |