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| ID | Type | Description | Link |
|---|---|---|---|
| A70210 | Other Identifier | WHO-TDR |
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A well-implemented community-based program of early and appropriate treatment of fevers/malaria episodes and pneumonia,will improve child survival as measured by a reduction of the less than five mortality rate.
An integrated approach of home and community management of malaria and pneumonia may increase the proportion of children receiving prompt treatment; improve child survival as measured by a reduction of the under five mortality rate. To test this hypothesis, a cluster randomised controlled trial will be performed, involving children less than 5 years of age, in Burkina Faso using a community-based supplying community health workers (CHWs), a core group of mothers (KOLs) with Coartem and cotrimoxazole specially packed in age-specific blisters containing a full course of treatment. The study will be carried out in 111 clusters of a rural district in Burkina Faso where malaria and pneumonia are two major mortality causes in under five mortality.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nothing at home level | No Intervention | No intervention at community level. The study drugs (arthemeter/Lumefantrine and Cotrimoxazole) available at the health facility drug stores level and prescribed exclusively to sick children attending to the health facility for care seeking. No Community Heath Worker /Key Opinion leader (CHWs/KOLs) selected in those clusters | |
| Home management of malaria | Experimental | At the community level, the Community health workers/ keay opinion leader (HWs/KOLs) trained and equipped to provide the antimalarial drug (arthemeter/Lumefantrine ) to any child with fever ("hot body") without any other signs of complications like impaired consciousness, convulsions, etc |
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| Home management of malaria and pneumonia | Experimental | At the community level, the Community health workers/ key opinion leader (HWs/KOLs) trained and equipped to provide the antimalarial drug (arthemeter/Lumefantrine ) or antibiotic (Cotrimoxazole) to any child with fever ("hot body") without any other signs of complications like impaired consciousness, convulsions, etc. The treatment decision making for the CHWs/KOLs based on the algorithm |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| home/community case management | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of death in children aged 6 to 59 months | annual crude mortality rate in children aged 0 to 6 months in the different study arms | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| - specific mortality preceded by acute febrile illness of children aged 6 to 59 months - severe malaria cases at community level | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events at community level consecutive to the administration of the cotrimoxazole and arthemeter/lumefantrine | 7 days after the administration of the drug |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sodiomon Bienvenu SIRIMA, MD, PhD | Groupe de Recherche Action en santé (GRAS), 06 BP 10248 Ouagadougou 06, Burkina Faso | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Groupe de Recherche Action en Sante (GRAS sarl) | Ouagadougou | Kadiogo | Burkina Faso |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33565123 | Derived | Oliphant NP, Manda S, Daniels K, Odendaal WA, Besada D, Kinney M, White Johansson E, Doherty T. Integrated community case management of childhood illness in low- and middle-income countries. Cochrane Database Syst Rev. 2021 Feb 10;2(2):CD012882. doi: 10.1002/14651858.CD012882.pub2. |
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| ID | Term |
|---|---|
| D008288 | Malaria |
| D011014 | Pneumonia |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
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| D000079426 |
| Vector Borne Diseases |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |