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The purpose of this study is to retrospectively and systematically review records of overweight and obese Medifast Weight Control Center (MWCC) members who have been assigned to the 5 & 2 & 2 Plan or the 4 & 2 & 1 Plan for weight loss to gain a better understanding of the effectiveness of these programs. The study will describe demographics of this population, along with weight loss, anthropometrics, body composition and effects on available cardiovascular parameters. Adherence to the plans will also be examined.
The study hypothesis is that the 5 & 2 & 2 Meal Replacement Plan and the 4 & 2 & 1 Meal Replacement Plan are both effective programs for weight loss in overweight and obese adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 5 & 2 & 2 Plan | MWCC members who used the Medifast 5 & 2 & 2 Meal Replacement Plan for weight loss. |
| |
| 4 & 2 & 1 Plan | MWCC members who used the Medifast 4 & 2 & 1 Meal Replacement Plan for weight loss. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 5 & 2 & 2 Plan | Other | Medifast has developed the 5 & 2 & 2 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 5 & 2 & 2 Plan consists of 5 Medifast meal replacements, 2 Lean & Green meals, and 2 healthy snacks and provides 1,200-1,400 kcal, >72g protein, >100g of carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack(s) included in this plans consists of a consumer selected serving of grain/starch, dairy, or fruit. |
| Measure | Description | Time Frame |
|---|---|---|
| Body Weight | The primary endpoint in this study is weight and the primary outcome is change from baseline body weight at 12 weeks for each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). Change from baseline will also be examined at other predetermined time points (e.g., 1, 2, 4, 8, 16, 20 and 24 weeks, and final weight loss visit - the mean length of time from baseline to the final weight loss visit was 18.06 weeks for the 5 & 2 & 2 Plan and 17.35 weeks for the 4 & 2 & 1 Plan.). | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 12 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight |
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Inclusion Criteria:
Exclusion Criteria:
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This study is a systematic retrospective chart review of existing MWCC charts located in Maryland, Texas, Florida or Pennsylvania for MWCC members who used either the Medifast 5 & 2 & 2 Plan or the Medifast 4 & 2 & 1 Plan for weight loss.
Charts will be reviewed for members that started either the 5 & 2 & 2 Plan or the 4 & 2 & 1 Plan on or after January 1, 2012. This start date was chosen because it represents the date when Medifast began using the current versions of the 5 & 2 & 2 Plan and the 4 & 2 & 1 Plan. Only charts of those members who are no longer in the active weight loss phase of their program at the MWCC will be considered for the study.
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| Name | Affiliation | Role |
|---|---|---|
| Linda M Aterburn, PhD | Medifast, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medifast, Inc. | Owings Mills | Maryland | 21117 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26245279 | Derived | Coleman CD, Kiel JR, Mitola AH, Langford JS, Davis KN, Arterburn LM. Effectiveness of a Medifast meal replacement program on weight, body composition and cardiometabolic risk factors in overweight and obese adults: a multicenter systematic retrospective chart review study. Nutr J. 2015 Aug 6;14:77. doi: 10.1186/s12937-015-0062-8. |
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This is a retrospective chart review of Medifast Weight Control Center (MWCC) clients from 21 centers that used either the Medifast 5 & 2 & 2 Plan or 4 & 2 & 1 Plan for weight loss between 1/2012 and 3/2014 - it is retropsective and observational in nature, so there was no recruitment involved. The plans were evaluated separately and not compared.
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| ID | Title | Description |
|---|---|---|
| FG000 | 5 & 2 & 2 Plan | MWCC members who used the Medifast 5 & 2 & 2 Meal Replacement Plan for weight loss. 5 & 2 & 2 Plan: Medifast has developed the 5 & 2 & 2 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 5 & 2 & 2 Plan consists of 5 Medifast meal replacements, 2 Lean & Green meals, and 2 healthy snacks and provides 1,200-1,400 kcal, >72g protein, >100g of carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack(s) included in this plans consists of a consumer selected serving of grain/starch, dairy, or fruit. |
| FG001 | 4 & 2 & 1 Plan | MWCC members who used the Medifast 4 & 2 & 1 Meal Replacement Plan for weight loss. 4 & 2 & 1 Plan: Medifast has developed the 4 & 2 & 1 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 4 & 2 & 1 Plan consists of 4 Medifast meal replacements, 2 Lean & Green meals, and 1 healthy snack, providing 1,000-1,200 kcal, >72g protein, >100g carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack included in this plans consist of a consumer selected serving of grain/starch, dairy, or fruit. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | 5 & 2 & 2 Plan | MWCC members who used the Medifast 5 & 2 & 2 Meal Replacement Plan for weight loss. 5 & 2 & 2 Plan: Medifast has developed the 5 & 2 & 2 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 5 & 2 & 2 Plan consists of 5 Medifast meal replacements, 2 Lean & Green meals, and 2 healthy snacks and provides 1,200-1,400 kcal, >72g protein, >100g of carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack(s) included in this plans consists of a consumer selected serving of grain/starch, dairy, or fruit. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Body Weight | The primary endpoint in this study is weight and the primary outcome is change from baseline body weight at 12 weeks for each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). Change from baseline will also be examined at other predetermined time points (e.g., 1, 2, 4, 8, 16, 20 and 24 weeks, and final weight loss visit - the mean length of time from baseline to the final weight loss visit was 18.06 weeks for the 5 & 2 & 2 Plan and 17.35 weeks for the 4 & 2 & 1 Plan.). | Posted | Mean | Standard Deviation | Pounds | 12 weeks |
|
Charts from MWCC customers that followed either the 5 & 2 & 2 Plan or the 4 & 2 & 1 Plan and met inclusion criteria who started their weight loss plan on or after January 1, 2012 and completed the active weight loss phase of their plan by March 31, 2014 (a total period of 2 years and 3 months).
This is a retrospective chart review study, and all of the signs, symptoms, and incidents reported were lay accounts by MWCC staff during the routine visits that were included as a part of customers' weight loss programs - not specifically as part of a clinical trial. Therefore, information normally associated with adverse events (relatedness, seriousness, etc.) was not collected. This description pertains to all events (all-cause mortality, serious adverse events, and other adverse events.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | 5 & 2 & 2 Plan | MWCC members who used the Medifast 5 & 2 & 2 Meal Replacement Plan for weight loss. 5 & 2 & 2 Plan: Medifast has developed the 5 & 2 & 2 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 5 & 2 & 2 Plan consists of 5 Medifast meal replacements, 2 Lean & Green meals, and 2 healthy snacks and provides 1,200-1,400 kcal, >72g protein, >100g of carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack(s) included in this plans consists of a consumer selected serving of grain/starch, dairy, or fruit. |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Stroke | Vascular disorders | Non-systematic Assessment |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| constipation | Gastrointestinal disorders | Non-systematic Assessment |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Chris Coleman | Medifast | 410-504-8161 | ccoleman@choosemedifast.com |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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|
| 4 & 2 & 1 Plan | Other | Medifast has developed the 4 & 2 & 1 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 4 & 2 & 1 Plan consists of 4 Medifast meal replacements, 2 Lean & Green meals, and 1 healthy snack, providing 1,000-1,200 kcal, >72g protein, >100g carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack included in this plans consist of a consumer selected serving of grain/starch, dairy, or fruit. |
|
The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). |
| 12 weeks |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 12 weeks |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 12 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 12 weeks |
| Waist Circumference | Waist circumference expressed as an absolute change from baseline. | 12 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 12 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 12 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 12 weeks |
| Blood Pressure Categorical | Blood pressure expressed as a categorical variable (normotensive, pre-hypertensive and hypertensive based on National Institute of Health Guidelines) with the percent of participants that improved (e.g. from hypertensive to pre-hypertensive or normal) their blood pressure category from baseline to 12 weeks. | 12 weeks |
| Resting Metabolic Rate | Resting metabolic rate expressed as an absolute change from baseline to final weight loss visit (The average length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Adherence | Adherence will be assessed through attendance at weekly visits and documented use of meal replacements at each visit. (Meal replacement adherence=average number of self-reported daily meal replacements through 12 weeks/nuber of prescribed meal replacements; Attendance adherence=number of visits/number of weeks on plan | 12 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 1 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 2 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 4 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 8 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 16 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 20 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | 24 weeks |
| Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans) at their final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 1 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 2 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 4 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 8 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 16 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 20 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | 24 weeks |
| Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans) at their final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 4 weeks |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 8 weeks |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 16 weeks |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 20 weeks |
| Lean Mass | Lean mass expressed as an absolute change from baseline. | 24 weeks |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 4 weeks |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 8 weeks |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 16 weeks |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 20 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 4 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 8 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 16 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 20 weeks |
| Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | 24 weeks |
| Waist Circumference | Waist circumference expressed as an absolute from baseline. | 4 weeks |
| Waist Circumference | Waist circumference expressed as an absolute change from baseline. | 8 weeks |
| Waist Circumference | Waist circumference expressed as an absolute change from baseline. | 16 weeks |
| Waist Circumference | Waist circumference expressed as an absolute change from baseline. | 20 weeks |
| Waist Circumference | Waist circumference expressed as an absolute change from baseline. | 24 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 4 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 8 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 16 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 20 weeks |
| Hip Circumference | Hip circumference expressed as an absolute change from baseline. | 24 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 1 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 2 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 4 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 8 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 16 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 20 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 24 weeks |
| Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline to final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Pulse | Pulse expressed as an absolute change from baseline. | 1 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 2 weeks |
| Pulse | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | 4 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 8 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 16 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 20 weeks |
| Pulse | Pulse expressed as an absolute change from baseline. | 24 weeks |
| Pulse | Pulse expressed as an absolute change from baseline to final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | 4 weeks |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | 8 weeks |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | 16 weeks |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | 20 weeks |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | 24 weeks |
| Adherence | Adherence will be assessed through documented use of meal replacements at each visit from baseline (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Body Weight | Change in body weight from baseline reported as absolute change. | 1 week |
| Body Weight | Change in body weight from baseline reported as absolute change from baseline. | 2 weeks |
| Body Weight | Change in body weight from baseline reported absolute change from baseline. | 4 weeks |
| Body Weight | Change in body weight from baseline reported as absolute change. | 8 weeks |
| Body Weight | Change in body weight from baseline reported as absolute change. | 16 weeks |
| Body Weight | Change in body weight from baseline reported as absolute change. | 20 weeks |
| Body Weight | Change in body weight from baseline to final weight loss visit reported as absolute change. (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.) | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
| Fat Mass | Fat mass expressed as an absolute change from baseline. | 24 weeks |
| BG001 | 4 & 2 & 1 Plan | MWCC members who used the Medifast 4 & 2 & 1 Meal Replacement Plan for weight loss. 4 & 2 & 1 Plan: Medifast has developed the 4 & 2 & 1 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 4 & 2 & 1 Plan consists of 4 Medifast meal replacements, 2 Lean & Green meals, and 1 healthy snack, providing 1,000-1,200 kcal, >72g protein, >100g carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack included in this plans consist of a consumer selected serving of grain/starch, dairy, or fruit. |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Weight | Mean | Standard Deviation | Pounds |
|
| BMI | Body Mass Index | Mean | Standard Deviation | kg/m2 |
|
| Lean Body Mass | Measured by bioelectrical impedance analysis | Mean | Standard Deviation | Pounds |
|
| Body Fat Mass | Measured by bioelectrical impedance analysis | Mean | Standard Deviation | Pounds |
|
| OG001 | 4 & 2 & 1 Plan | MWCC members who used the Medifast 4 & 2 & 1 Meal Replacement Plan for weight loss. 4 & 2 & 1 Plan: Medifast has developed the 4 & 2 & 1 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 4 & 2 & 1 Plan consists of 4 Medifast meal replacements, 2 Lean & Green meals, and 1 healthy snack, providing 1,000-1,200 kcal, >72g protein, >100g carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack included in this plans consist of a consumer selected serving of grain/starch, dairy, or fruit. |
|
|
|
| Secondary | Percentage of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | percentage of subjects | 12 weeks |
|
|
|
| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | percentage of subjects | 12 weeks |
|
|
|
| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Not all subjects remaining at 12 weeks had body composition testing performed. | Posted | Mean | Standard Deviation | Pounds | 12 weeks |
|
|
|
| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Not all subjects remaining at 12 weeks had body composition testing performed. | Posted | Mean | Standard Deviation | Pounds | 12 weeks |
|
|
|
| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Not all subjects remaining at 12 weeks had measurement performed. | Posted | Mean | Standard Deviation | Inches | 12 weeks |
|
|
|
| Secondary | Waist Circumference | Waist circumference expressed as an absolute change from baseline. | Not all subjects remaining at 12 weeks had measurement performed. | Posted | Mean | Standard Deviation | Inches | 12 weeks |
|
|
|
| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Not all subjects remaining at 12 weeks had measurement performed. | Posted | Mean | Standard Deviation | Inches | 12 weeks |
|
|
|
| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 12 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 12 weeks |
|
|
|
| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Not all subjects were remaining at 12 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | Beats per minute | 12 weeks |
|
|
|
| Secondary | Blood Pressure Categorical | Blood pressure expressed as a categorical variable (normotensive, pre-hypertensive and hypertensive based on National Institute of Health Guidelines) with the percent of participants that improved (e.g. from hypertensive to pre-hypertensive or normal) their blood pressure category from baseline to 12 weeks. | Not all subjects were remaining at 12 weeks and not all had measurement performed. | Posted | Number | Percent of participants | 12 weeks |
|
|
|
| Secondary | Resting Metabolic Rate | Resting metabolic rate expressed as an absolute change from baseline to final weight loss visit (The average length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Number of participants with paired data at baseline and final weight loss visit was too small for meaningful analysis. | Posted | Mean | Standard Deviation | calories | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
|
|
|
| Secondary | Adherence | Adherence will be assessed through attendance at weekly visits and documented use of meal replacements at each visit. (Meal replacement adherence=average number of self-reported daily meal replacements through 12 weeks/nuber of prescribed meal replacements; Attendance adherence=number of visits/number of weeks on plan | Posted | Mean | Standard Deviation | Percent Compliant | 12 weeks |
|
|
|
| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 1 weeks |
|
|
|
| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 2 weeks |
|
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 4 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 8 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 16 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 20 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 24 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 5% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 5% of baseline body weight while on each plan (5 & 2 & 2 and 4 & 2 & 1 Plans) at their final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Posted | Number | Percent of subjects | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 1 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 2 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 4 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 8 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 16 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 20 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans). | Posted | Number | Percent of subjects | 24 weeks |
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| Secondary | Proportion of Subjects Who Lose at Least 10% of Baseline Body Weight | The categorical endpoint of the proportion of subjects who lose at least 10% of baseline body weight while on each program (5 & 2 & 2 and 4 & 2 & 1 Plans) at their final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Posted | Number | Percent of subjects | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 4 weeks |
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| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 8 weeks |
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| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 16 weeks |
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| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 20 weeks |
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| Secondary | Lean Mass | Lean mass expressed as an absolute change from baseline. | Not all subjects were remaining at 24 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | Pounds | 24 weeks |
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| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 4 weeks |
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| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 8 weeks |
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| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 16 weeks |
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| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 20 weeks |
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| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 4 weeks |
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| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 8 weeks |
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| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 16 weeks |
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| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 20 weeks |
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| Secondary | Abdominal Circumference | Abdominal circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 24 weeks |
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| Secondary | Waist Circumference | Waist circumference expressed as an absolute from baseline. | Posted | Mean | Standard Deviation | Inches | 4 weeks |
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| Secondary | Waist Circumference | Waist circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 8 weeks |
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| Secondary | Waist Circumference | Waist circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 16 weeks |
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| Secondary | Waist Circumference | Waist circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 20 weeks |
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| Secondary | Waist Circumference | Waist circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 24 weeks |
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| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 4 weeks |
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| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 8 weeks |
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| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 16 weeks |
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| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 20 weeks |
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| Secondary | Hip Circumference | Hip circumference expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Inches | 24 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | mmHg | 1 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 2 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 2 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 4 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 4 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 8 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 8 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 16 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 16 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 20 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 20 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Not all subjects were remaining at 24 weeks and not all had measurement performed. | Posted | Mean | Standard Deviation | mmHg | 24 weeks |
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| Secondary | Blood Pressure | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline to final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Not all subjects had measurement performed at their final visit. | Posted | Mean | Standard Deviation | mmHg | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 1 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | mmHg | 2 weeks |
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| Secondary | Pulse | Blood pressure (systolic and diastolic) expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 4 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 8 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 16 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 20 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline. | Posted | Mean | Standard Deviation | Beats per minute | 24 weeks |
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| Secondary | Pulse | Pulse expressed as an absolute change from baseline to final weight loss visit (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Posted | Mean | Standard Deviation | Beats per minute | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | Posted | Mean | Standard Deviation | Percent compliance meal replacements | 4 weeks |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | Posted | Mean | Standard Deviation | Percent compliance meal replacements | 8 weeks |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | Posted | Mean | Standard Deviation | Percent compliance meal replacements | 16 weeks |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | Posted | Mean | Standard Deviation | Percent compliance meal replacements | 20 weeks |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit. | Posted | Mean | Standard Deviation | Percent compliance meal replacements | 24 weeks |
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| Secondary | Adherence | Adherence will be assessed through documented use of meal replacements at each visit from baseline (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.). | Posted | Mean | Standard Deviation | Percent compliance meal replacements | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Body Weight | Change in body weight from baseline reported as absolute change. | Posted | Mean | Standard Deviation | Pounds | 1 week |
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| Secondary | Body Weight | Change in body weight from baseline reported as absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 2 weeks |
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| Secondary | Body Weight | Change in body weight from baseline reported absolute change from baseline. | Posted | Mean | Standard Deviation | Pounds | 4 weeks |
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| Secondary | Body Weight | Change in body weight from baseline reported as absolute change. | Posted | Mean | Standard Deviation | Pound | 8 weeks |
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| Secondary | Body Weight | Change in body weight from baseline reported as absolute change. | Posted | Mean | Standard Deviation | Pounds | 16 weeks |
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| Secondary | Body Weight | Change in body weight from baseline reported as absolute change. | Posted | Mean | Standard Deviation | Pounds | 20 weeks |
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| Secondary | Body Weight | Change in body weight from baseline to final weight loss visit reported as absolute change. (The mean length of time from baseline to the final weight loss visit was 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan.) | Posted | Mean | Standard Deviation | Pounds | Baseline to final weight loss visit (Average of 18 weeks for the 5 & 2 & 2 Plan and 17 weeks for the 4 & 2 & 1 Plan) |
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| Secondary | Fat Mass | Fat mass expressed as an absolute change from baseline. | Not all subjects remaining at 24 weeks had body composition testing performed. | Posted | Mean | Standard Deviation | Pounds | 24 weeks |
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| 0 |
| 62 |
| 2 |
| 62 |
| 46 |
| 62 |
| EG001 | 4 & 2 & 1 Plan | MWCC members who used the Medifast 4 & 2 & 1 Meal Replacement Plan for weight loss. 4 & 2 & 1 Plan: Medifast has developed the 4 & 2 & 1 Plan as a higher calorie and higher carbohydrate alternative. This plan may be selected for very obese (BMI ≥ 40kg/m2) or older (>65 years) individuals, or for medical (e.g., diabetes) or behavioral reasons (individuals engages in high levels of physical activity). The 4 & 2 & 1 Plan consists of 4 Medifast meal replacements, 2 Lean & Green meals, and 1 healthy snack, providing 1,000-1,200 kcal, >72g protein, >100g carbohydrate, and <30% of calories from fat. The Lean & Green meal is consumer selected and consists of 5-7 ounces of a lean protein, 1 ½ - 3 cups of non-starchy vegetables, and up to 2 healthy fat servings. The healthy snack included in this plans consist of a consumer selected serving of grain/starch, dairy, or fruit. | 0 | 310 | 9 | 310 | 219 | 310 |
| Heart attack | Cardiac disorders | Non-systematic Assessment |
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| cholecystectomy | Surgical and medical procedures | Non-systematic Assessment |
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| Bloot clot | Vascular disorders | Non-systematic Assessment |
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| Fever | Infections and infestations | Non-systematic Assessment |
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| Ruptured hemorrhoid | Surgical and medical procedures | Non-systematic Assessment |
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| Mini-stroke | Vascular disorders | Non-systematic Assessment |
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| Hospitalization | General disorders | Non-systematic Assessment | Reason for hospitalizations was not specified in these 2 cases. |
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| gas/bloating | Gastrointestinal disorders | Non-systematic Assessment |
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| hunger | General disorders | Non-systematic Assessment |
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| fatigue | General disorders | Non-systematic Assessment |
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| stress/anxiety | General disorders | Non-systematic Assessment |
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| Sick Not Otherwise Specified | General disorders | Non-systematic Assessment |
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| cravings | General disorders | Non-systematic Assessment |
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| Headache | General disorders | Non-systematic Assessment |
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Not provided
Not provided
Not provided
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |