Prevention of Postoperative Bleeding in Subcapital Femoral Fractures

Prevention of Postoperative Bleeding in Femoral Fractures: a Multicenter, Randomized, Controlled, Parallel Clinical Trial to Assess the Efficacy of Tranexamic Acid and Fibrin Glue

The main hypothesis of this clinical trial is that the use of intra-articular tranexamic acid and the fibrin glue plus usual hemostasis will reduce at least a 25% the postoperative blood loss with respect to usual hemostasis in patients undergoing subcapital femoral fractures.

Inclusion Criteria:

• Patients over 18 years
• Patients with unilateral subcapital femoral fracture
• Patients requiring hip replacement (total or partial)
• Signed informed consent from the patient or legal representative

Exclusion Criteria:

• Known allergy to fibrin glue and tranexamic acid

• Multiple fractures

• Pathological fractures

• Contraceptives or estrogen therapy

• Use of blood salvage during surgery

• History compatible with thromboembolic disease:

  • Cerebral vascular accident
  • Ischemic heart disease (myocardial infarction, angina )
  • Deep vein thrombosis
  • Pulmonary Embolism
  • Peripheral arterial vasculopathy
  • Patients with thrombogenic arrhythmias
  • Patients with cardiovascular stents
  • Prothrombotic alterations in coagulation