Multi-center, randomized , double-blind, placebo-controlled , two arm parallel design study of NeuroVax™ vs. Incomplete Freund's Adjuvant ( I F A) placebo. 150 subjects with Secondary Progressive SPMS.

The primary objective is to compare between treatment groups the Measures of neurologic disability EDSS scores.

Inclusion Criteria:

• Ages Eligible for Study: 18 Years to 70 Years
• Genders Eligible for Study: Both
• Accepts Healthy Volunteers: No Criteria
• Subject is between 18 and 70 years of age, inclusive.
• Definite MS by the revised McDonald criteria (2005) (Appendix A), with a Secondary Progressive course.
• Expanded Disability Status Scale (EDSS) >=score 3.5 (Appendix B).
• Two or more documented clinical relapses of MS in the preceding 24 months OR one documented clinical relapse of MS in the preceding 1 2 months prior to screening .
• Laboratory values within the following limits:
• Creatinine 1 . 5 x high normal.
• Hemoglobin

Exclusion Criteria:

• Subjects currently prescribed Campath or Lemtrada