Oxygen Therapy in Depression

Oxygen Therapy in Depression

The major objective of the present study is to examine the influence of normobaric hyperoxia treatment on the symptoms of patients diagnosed with depression members of Clalit Health Services. The investigators hypothesize that normobaric hyperoxia treatment will improve the symptoms of patients with depression.

Inclusion Criteria:

• Men and women aged 18-65 years diagnosed with mild to moderate depression.

Exclusion Criteria:

• Patients with oxygen saturation below 95%;
• An unstable mental (psychiatric) condition
• A psychiatric condition that requires a change in pharmacotherapy (importantly - medications will not be changed in patients who will be enrolled to the study)
• Acute or chronic respiratory disease
• Any severe physical illness
• Suicidal thoughts or attempts
• Drug abuse
• Obesity (BMI over 30)
• Inability to cease smoking during night hours while participants are supposed to be using the oxygen/air supplementing machine.