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| ID | Type | Description | Link |
|---|---|---|---|
| MNEURT ISCHEMIC STROKE 813 | Other Identifier | HUCH |
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| Name | Class |
|---|---|
| HUS area Prehospital Emergency Service | UNKNOWN |
The aim of this study is to establish diagnostic and predictive biomarkers for patients with suspected acute stroke, that are transported by EMS as candidates for thrombolytic treatment. The study focuses on the ultra acute phase, <4.5 hours from symptom onset, including the prehospital setting. Analyses will include known biomarkers (e.g. GFAP, NR2 peptide) and a discovery phase for novel markers. Patient outcome will be evaluated at 3 month using the modified Rankin Scale (mRS).
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| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic accuracy of biomarkers for identifying ischemic stroke, transient ischemic attack, intracerebral hemorrhage and stroke mimics. | Metrics: Receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, negative predictive value | 90 days +/- 5 days |
| Predictive accuracy of biomarkers for identifying patients not responding to thrombolytic treatment. | Metrics: Receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, negative predictive value | 90 days +/- 5 days |
| Predictive accuracy of biomarkers for identifying patients facing hemorrhagic complications of thrombolytic treatment | Metrics: Receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, negative predictive value | 90 days +/- 5 days |
| Predictive accuracy of biomarkers for predicting outcome | Metrics: Receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, negative predictive value | 90 days +/- 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with suspected acute stroke, being transported by emergency medical services (EMS) to a tertiary hospital stroke center, as candidates for thrombolytic treatment of acute ischemic stroke.
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| Name | Affiliation | Role |
|---|---|---|
| Perttu Lindsberg, MD, PhD | Helsinki University Central Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helsinki University Central Hospital | Helsinki | Uusimaa | 00290 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30758276 | Derived | Mattila OS, Puolakka T, Ritvonen J, Pihlasviita S, Harve H, Alanen A, Sibolt G, Curtze S, Strbian D, Pystynen M, Tatlisumak T, Kuisma M, Lindsberg PJ. Targets for improving dispatcher identification of acute stroke. Int J Stroke. 2019 Jun;14(4):409-416. doi: 10.1177/1747493019830315. Epub 2019 Feb 13. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Human Serum and Plasma
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |