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The goal of the present study was to investigate the role of pro-inflammatory cytokines in myocardial dysfunction and injury resulting from noncardiac injury in children and whether or not anti-inflammatory treatment with caudal block prevents pro-inflammatory cytokines-associated myocardial dysfunction and injury following noncardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ropivacaine | Experimental | caudal block with 1 ml/kg of ropivacaine 0.2% |
|
| saline | Placebo Comparator | caudal block with 1 ml/kg of saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ropivacaine | Drug | caudal block with 1 ml/kg of ropivacaine 0.2% |
| |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at arrival in the postanesthesia care unit | baseline(before induction of anesthesia), arrival in the postanesthesia care unit | |
| change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 3h after surgery | baseline(before induction of anesthesia), 3h after surgery | |
| change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 24h after surgery | baseline(before induction of anesthesia), 24h after surgery | |
| change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 48h after surgery | baseline(before induction of anesthesia), 48h after surgery | |
| change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 72h after surgery | baseline(before induction of anesthesia), 72h after surgery | |
| change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at arrival in the postanesthesia care unit | baseline(before induction of anesthesia), arrival in the postanesthesia care unit | |
| change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 3h after surgery | baseline(before induction of anesthesia), 3h after surgery | |
| change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 24h after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline(just before the start of surgery) in MAP(mean arterial pressure) at arrival in the postanesthesia care unit | baseline(just before the start of surgery), at arrival in the postanesthesia care unit | |
| change from baseline(just before the start of surgery) in MAP(mean arterial pressure) at 3h after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| SiQin Chen, MD | Contact | +8613918085974 | chensiqin1983@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xinhua Hospital | Recruiting | Shanghai | 200092 | China |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| saline |
| Drug |
caudal block with 1 ml/kg of saline |
|
| baseline(before induction of anesthesia), 24h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 48h after surgery | baseline(before induction of anesthesia), 48h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 72h after surgery | baseline(before induction of anesthesia), 72h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at arrival in the postanesthesia care unit | baseline(before induction of anesthesia), arrival in the postanesthesia care unit |
| change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 3h after surgery | baseline(before induction of anesthesia), 3h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 24h after surgery | baseline(before induction of anesthesia), 24h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 48h after surgery | baseline(before induction of anesthesia), 48h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 72h after surgery | baseline(before induction of anesthesia), 72h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at arrival in the postanesthesia care unit | baseline(before induction of anesthesia), arrival in the postanesthesia care unit |
| change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 3h after surgery | baseline(before induction of anesthesia), 3h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 24h after surgery | baseline(before induction of anesthesia), 24h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 48h after surgery | baseline(before induction of anesthesia), 48h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 72h after surgery | baseline(before induction of anesthesia), 72h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at arrival in the postanesthesia care unit | baseline(before induction of anesthesia), arrival in the postanesthesia care unit |
| change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 3h after surgery | baseline(before induction of anesthesia), 3h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 24h after surgery | baseline(before induction of anesthesia), 24h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 48h after surgery | baseline(before induction of anesthesia), 48h after surgery |
| change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 72h after surgery | baseline(before induction of anesthesia), 72h after surgery |
| baseline(just before the start of surgery), 3h after surgery |
| change from baseline(just before the start of surgery) in CVP(central venous pressure) at arrival in the postanesthesia care unit | baseline(just before the start of surgery), at arrival in the postanesthesia care unit |
| change from baseline(just before the start of surgery) in CVP(central venous pressure) at 3h after surgery | baseline(just before the start of surgery), 3h after surgery |
| change from baseline(just before the start of surgery) in HR(heart rate) at arrival in the postanesthesia care unit | baseline(just before the start of surgery), at arrival in the postanesthesia care unit |
| change from baseline(just before the start of surgery) in HR(heart rate) at 3h after surgery | baseline(just before the start of surgery), 3h after surgery |
| D000588 |
| Amines |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |