A Study to Evaluate the Safety of Electronic Vapor Products for 2 Years

A Multi-Centre Study to Evaluate the Safety of Use of Electronic Vapour Products for Two Years

Electronic Vapour Products (EVPs) is a relatively new class of consumer products that are otherwise known as electronic cigarettes devices/systems. These may look like conventional cigarettes but do not contain tobacco.

The 'vapour' produced by such devices typically consists of humectants (propylene glycol or glycerol), nicotine, water, and flavours.

This trial is to evaluate the safety and tolerability of an EVP over two years.

Inclusion Criteria:

• Subject who participated in the EVP G1 S2 study (S2)
• Willingness to use the EVP provided by the sponsor for two years as the only nicotine containing product
• No clinically significant abnormalities during the S2 study

Exclusion Criteria:

• Subjects who have used nicotine replacement therapy during the S2 study
• Subjects with relevant illness history
• Subjects with history of drug or alcohol abuse
• Subjects with lung function test or vital signs considered unsuitable Subjects who are trying to stop smoking
• Female subjects who are pregnant, or unwilling to use acceptable contraceptive method for the duration of the study.