Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal

Double-blind, Placebo-controlled Randomized Controlled Trial of NSAID Prior to Ureteral Stent Removal in a Pediatric Population

This study plans to learn more about whether ibuprofen can reduce pain after removal of a ureteral stent more than a placebo. Some patients experience pain after removal of a ureteral stent. The investigators plan to learn how often this occurs and whether it can be prevented.

The investigators hypothesize that children who have a temporary, indwelling ureteral stent will experience a significantly less post-operative pain if given a non-steroidal anti-inflammatory (NSAID) prior to removal of the ureteral stent when compared to placebo. The investigators hypothesize that the incidence of severe post-stent removal pain is similar to an adult population.

Inclusion Criteria:

• ages 4-17
• unilateral ureteral stent placed after ureteropelvic junction obstruction repair or treatment of upper tract urolithiasis

Exclusion Criteria:

• bilateral stents
• undergoing other concomitant procedure at time of planned ureteral stent removal
• indication for stent other than ureteropelvic junction obstruction repair or treatment of upper tract urolithiasis
• pregnant
• developmental delay
• allergy to ibuprofen or non-steroidal anti-inflammatory medication class
• chronic kidney disease
• prior renal transplant
• history of nasal polyps
• history of asthma