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Obesity is a major health issue worldwide; there is a constant raise in obesity related death each year. In vitro and animal studies elucidated Hippophae rhamnoides L. Leaf Extract as a novel anti-obesity agent. However, the efficacy and safety of Hippophae rhamnoides L. Leaf Extract supplementation on body weight regulation in humans are lacking.
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of Hippophae rhamnoides L. Leaf Extract on body fat. The investigators measured Body Fat Mass, Percent Body Fat, Fat Free Mass, weight, and body mass index.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hippophae rhamnoides L. Leaf Extract | Experimental | Hippophae rhamnoides L. Leaf Extract 3g/day |
|
| Placebo | Placebo Comparator | Placebo 3g/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hippophae rhamnoides L. Leaf Extract (3g/day) | Dietary Supplement | Hippophae rhamnoides L. Leaf extract (3g/day), parallel design |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in body fat mass | Body fat mass was measured in study baseline and visit 3(12 week). | Baseline and 12 week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in percent body fat | Percent body fat was measured in study baseline and visit 3(12 week). | Baseline and 12 week |
| Change in fat free mass | Fat Free Mass was measured in study baseline and visit 3(12 week). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chonbuk National University Hospital | Jeonju | Jeollabuk-do | 561-712 | South Korea |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo (3g/day) | Dietary Supplement | Placebo (3g/day), parallel design |
|
| Baseline and 12 week |
| Change in weight | Weight was measured in study baseline and visit 3(12 week). | Baseline and 12 week |
| Change in body mass index | Body mass index was measured in study baseline and visit 3(12 week). | Baseline and 12 week |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |