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The purpose of this study is to evaluate the drug-drug interaction between amlodipine/losartan and rosuvastatin in healthy male volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1 | Experimental | amosartan → rosuvastatin → amosartan and rosuvastatin |
|
| Sequence 2 | Experimental | rosuvastatin → amosartan and rosuvastatin → amosartan |
|
| Sequence 3 | Experimental | amosartan and rosuvastatin → amosartan → rosuvastatin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| amosartan | Drug |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Cmax | 0-72h | |
| AUClast | 0-72h |
| Measure | Description | Time Frame |
|---|---|---|
| tmax | 0-72h | |
| t1/2 | 0-72h | |
| AUCinf | 0-72h |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin-A Jung, Ph.D | Contact | jajung@hanmi.co.kr |
| Name | Affiliation | Role |
|---|---|---|
| JaeWook Ko, M.D. | Samsung Seoul Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samgsung Seoul Hospital | Recruiting | Seoul | South Korea |
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| ID | Term |
|---|---|
| D000068718 | Rosuvastatin Calcium |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D005464 | Fluorobenzenes |
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| rosuvastatin |
| Drug |
|
|
| amosartan and rosuvastatin | Drug |
|
|
| D006845 |
| Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |