Thrombin Generation and Gestational Outcome

Thrombin Generation and Gestational Outcome in Women With Recurrent Pregnancy Loss

In total 120 pregnant women's with history of recurrent miscarriages, are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. The investigators will measure the thrombin generation in plasma assessed by the calibrated automated thrombogram (CAT). The relation between pregnancy outcome and thrombin measurements will be determined

Inclusion Criteria:

• age > 18
• signed inform consent
• first trimester
• two early miscarriages(before week 10) or one later abortions (after week 10)

Exclusion Criteria:

• Chronic treatment with aspirin or other anticoagulants