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Insulin-like growth factor 1 (IGF)-1 is an important neuromyotrophic hormone. Disregulation of this hormone has been reported to influence the genesis of cognitive impairment and dementia in the elderly patients. We analyzed the possible link between IGF-1 and risk of Sarcopenia and Mortality in a cohort of elder patients with cognitive impairment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IGF-1 1st and 2nd quartile | Reduction of IGF-1 serum value in a cohort of patients with cognitive impairment |
| |
| IGF-1 3rd and 4rd quartile | Reduction of IGF-1 serum value in a cohort of patients with cognitive impairment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IGF-1 serum value | Procedure | Evaluation of IGF-1 serum value at baseline, 24 and 48 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| IGF-1 reduction in patients with sarcopenia | IGF-1 reduction could be linked to sarcopenia in patients with cognitive impairment | baseline, 24 months, 48 months |
| Measure | Description | Time Frame |
|---|---|---|
| IGF-1 reduction and mortality in patients with cognitive impairment | IGF-1 could be an independent risk factor for mortality in patients with cognitive impairment | baseline, 24 months, 48 months |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients were enrolled from orthopedics clinic (IRCCS Galeazzi Milan) and geriatric day service (Sapienza University of Rome)
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| Name | Affiliation | Role |
|---|---|---|
| Vincenzo Gianturco, MD | University of Roma La Sapienza | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Galeazzi | Milan | Italy | Italy | |||
| Sapienza University of Rome |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D009133 | Muscular Atrophy |
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| Rome |
| Italy |
| 00161 |
| Italy |
| D020879 |
| Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |