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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
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Primary hypothesis:
A large reduction in weight is not associated with a change in accurately measured glomerular filtration rate (GFR) (51Chromium ethylenediaminetetraacetic acid plasma clearance (51Cr-EDTA)).
Secondary hypothesis:
A large reduction in weight is associated with a greater change in estimated GFR (The Modification of Diet in Renal Disease (MDRD-formula)) than in accurately measured GFR.
Other formulas for estimated GFR (Cockcroft Gault, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI with cystatin C) are better correlated with accurately measured GFR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bariatric surgery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gastric by-pass surgery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in accurately measured GFR | Up to 6 months and 18 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Change in estimated GFR (as measured by the MDRD formula, the Cockcroft Gault formula, CKD-EPI formula and CKD-EPI with cystatin C formula). | Up to 6 months and 18 months after surgery | |
| Change in 24hour blood pressure | Up to 6 months and 18 months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Rossing, Professor | Steno Diabetes Center Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peter Rossing | Gentofte Municipality | 2820 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28166744 | Derived | von Scholten BJ, Persson F, Svane MS, Hansen TW, Madsbad S, Rossing P. Effect of large weight reductions on measured and estimated kidney function. BMC Nephrol. 2017 Feb 6;18(1):52. doi: 10.1186/s12882-017-0474-0. |
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| Change in arterial stiffness (as measured by sphygmocor) | Up to 6 months and 18 months after surgery |
| Change in body composition, as measured by Dual-energy X-ray absorptiometry scan (DXA-scan) | Up to 6 months and 18 months after surgery |
| Change in accurately measured GFR compared with change in estimated GFR | Up to 6 months and 18 months after surgery |