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It is a double blind controlled study to test the hypothesis that Topiramate is more effective than placebo in the treatment of compulsive buying, during a period of 12 weeks
Compulsive buying is a prevalent disorder with no approved pharmacological treatment. Previous reports suggest that topiramate could be useful in reducing impulsivity in pathological gambling and other impulse control disorders, as well as craving in substance addictions. The goal of this study was to investigate the effectiveness of topiramate combined with brief cognitive restructuring in treating compulsive buying, compared with just cognitive restructuring treatment+placebo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | a 12 week placebo matching tablets plus 4 sessions of a manualized cognitive restructuring intervention |
|
| topiramate | Experimental | a 12 week topiramate flexible dose administration plus 4 sessions of a manualized cognitive restructuring intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topiramate | Drug |
| ||
| Cognitive restructuring intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Yale-Brown Compulsive-Obsessive Scale Shopping Version | It is a revised version of the Yale-Brown Obsessive-Compulsive Scale (YBOCS), created to assess both the cognitive and behaviour of compulsive buying as well as to rate the severity of the problem | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impression scale (CGI) | The CGI scale quantifies the severity of disease and the effects of treatment, as well as overall clinical improvement. | 12 weeks |
| Udvalg for KliniskeUndersøgelser Side Effect Rating Scale (UKU) |
| Measure | Description | Time Frame |
|---|---|---|
| Social adjustment | The social Adjustment scale (SAS) is a self-report scale that assesses seven specific areas: work, social, life and leisure, extended family relationship, marital relationship, relationship with offsprings, domestic life and financial situation | 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hermano Tavares, Professor | associate | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Associação Viver Bem | São Paulo | São Paulo | 05404-010 | Brazil |
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| Label | URL |
|---|---|
| Non for profit organization that supports Impulse Control patients and their relatives | View source |
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| ID | Term |
|---|---|
| D000077236 | Topiramate |
| ID | Term |
|---|---|
| D005632 | Fructose |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 |
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4 sessions of a manualized cognitive restructuring intervention for compulsive buying |
|
|
It was developed to provide a comprehensive side effect rating scale with well-defined and operationalized items to assess the side effects of psychopharmacological medications.
| 12 weeks |
| Carbohydrates |
| D007661 | Ketoses |