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| ID | Type | Description | Link |
|---|---|---|---|
| H133G130200 | Other Grant/Funding Number | National Institute on Disability and Rehabilitation Research (NIDRR) |
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| Name | Class |
|---|---|
| Children's Hospital Colorado | OTHER |
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The purpose of this study is to investigate longitudinally, the walking ability of individuals with cerebral palsy who are transitioning into adulthood and to cross-sectionally examine the health status of these individuals in the context of their walking ability. Young adults who received instrumented gait analysis (IGA) as children will show significant decreases in overall gait performance, as measured by kinematics, kinetics, temporal-spatial parameters, and gait deviation index, compared to their last childhood IGA.
The investigators are proposing a prospective, longitudinal, cross-sectional, and patient-centered outcome study of walking ability and current health status to investigate important health outcomes that impact the quality of life, participation, and activity on adults with cerebral palsy who took part in a gait analysis during childhood at the Center for Gait and Movement Analysis (CGMA). The goal is to see whether their health and walking ability has changed since leaving the Children's Hospital Colorado (CHCO) system and understand if there is a relationship between maintaining proper walking ability and health status. The investigators are including the measure of health outcomes to better understand if a decline in walking ability relates to a decline in health status. The first aim is to study the walking ability of adults with cerebral palsy by comparing their results of a gait analysis to the same results collected when they were children. The second aim is to study the presence of heart disease risk factors by testing each participant's blood levels of lipids, glucose, and insulin. The investigators will also measure each participant's blood pressure. The third aim is to study the relationship(s) between inflammatory markers, neurotrophic factors, and pain and fatigue levels. The investigators will measure inflammatory markers through a blood test and pain and fatigue levels through standardized assessments. The fourth aim is to study each participant's mental health. The investigators will measure this through standardized psychological assessments. The fifth aim is to study each participant's self-perceived health and quality of life as well as employment status. The investigators will measure these levels also through standardized assessments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cerebral Palsy | Patients with cerebral palsy who were seen at the Center for Gait and Movement Analysis (CGMA) at Children's Hospital Colorado as children. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Instrumented Gait Analysis (IGA) at up to 15 years | Kinematics - joint angles and positions during over-ground walking. Kinetics - forces measured from force plates during over-ground walking. Gait Deviation Index - overall gait performance score measured from kinematics. Electromyography - measure of muscle activity during over-ground walking. Physical Exam - measure of joint range of motion and muscle strength. | baseline and up to 15 years |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic, Inflammatory, and Neurotrophic Markers Blood Samples | Blood will be drawn during 1 study visit after fasting for 12 hours. Several different blood analyses will be run on the sample. Blood will not be banked. | one time-point cross-sectional study |
| Fatigue Measure |
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Inclusion Criteria:
Exclusion Criteria:
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Cohort will be selected from a larger cohort of 400 patients that received full, instrumented gait analyses as children at the Center for Gait and Movement Analysis at Children's Hospital Colorado and who are now older than 18.
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| Name | Affiliation | Role |
|---|---|---|
| James J Carollo, Ph.D. | University of Colorado Denver, Anschutz Medical Campus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital Colorado | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D002547 | Cerebral Palsy |
| D020233 | Gait Disorders, Neurologic |
| ID | Term |
|---|---|
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Muscle fatigue will be measured by the Moreau Fatigue Index. This test is performed by doing repeated maximum voluntary concentric knee flexion and extensions at 60 degrees/sec for 35 repetitions. |
| one time-point cross-sectional study |
| NIH Patient Reported Outcomes Measurement System (PROMIS) and Health-Related Quality of Life | Questionnaire measures of patients symptoms, functioning, and health-related quality of life. | one time-point cross-sectional study |
| Employment Status | Demographic data collection using a questionnaire. | one time-point cross-sectional study |
| The World Health Organization Disability Assessment Schedule (WHODAS II) | Instrument providing a global measure of disability across six domains. | one time-point cross-sectional study |
| Self-Efficacy | General Self-Efficacy Scale-12 (GSES-12) assess a general sense of perceived self-efficacy with th eaim to evaluate coping with daily hassles as well as adaptation after experiencing stressful life events | one time-point cross-sectional study |
| Life Style Assessments | Self-Rated Abilities for Health Practices Scale (SRAHP) - 28-item 5-point scale to measure self-perceived ability to implement health-promoting behaviors. Comprehensive Health Assessment Motivation Program (CHAMP)/Health & Wellness Passport - checklist of daily lifestyle and fitness choices that contribute to individuals personal success. | one time-point cross-sectional study |
| Cognitive Battery | Subtests of Wechsler Adult Intelligence Score IV/Wechsler Memory Scale IV (WAIS IV/WMS IV) - standardized psychological evaluation. Verbal Fluency - subject generates as many words belonging to one semantic category. NIH Toolbox Cognitive Battery - computerized adaptive test principles to measure cognitive function. | one time-point cross-sectional study |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |