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| Name | Class |
|---|---|
| University of Glasgow | OTHER |
| University Of Nigeria Teaching Hospital | NETWORK |
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An ongoing case study of psoriasis, shows reproducibly that ingestion of hydrogenated fats, and some flavourant or sweetener compounds, leads to relapse of psoriasis, and secondary food intolerances, followed by remission over a couple of months (cpcpsoriasis.blogspot.com). Hence a personalized categorical food avoidance diet averts relapse and maintains remission of psoriasis, with side benefit on blood pressure and other metabolic parameters (J Hypertension 2012; 30: e-suppl 1, poster 158). Study hypothesis: this dietary approach would improve the control of essential hypertension. A randomized controlled clinical trial is proposed to compare this dietary approach with conventional DASH-type dietary counselling. 40 study participants will be randomly assigned to either conventional or interventional dietary counselling. They will be comprehensively monitored (including gene expression studies) for two years. Outcome criteria will include blood pressure, complications of hypertension, side-benefit on comorbidity, and requirement for antihypertensive drugs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PCFA interventional dietary counselling | Active Comparator | personalized categorical food avoidance dietary counselling |
|
| conventional DASH diet counselling | Sham Comparator | DASH = conventional "dietary approach to stop hypertension" |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PCFA interventional dietary counselling | Other |
| ||
| conventional DASH diet counselling |
| Measure | Description | Time Frame |
|---|---|---|
| a statistically significant 12 mm Hg (or more) greater change of blood pressure in one group compared to the other | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| resolution of hypertension (normal blood pressure, no drugs required) | 2 years | |
| serious (disabling) adverse events attributable to hypertension or its drug treatment | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| a reduction in antihypertensive treatment required i.e. reduced number of drugs required, or dosage of at least two drugs reduced by half | 2 years |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nnamdi Nwosu, MB BS FWACP | Contact | +2348037123803 | dykenig@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Chioli P Chijioke, MA MB BChir MD | College of Medicine, University of Nigeria | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chiolive International Medical Research Organisation | Recruiting | Enugu | Enugu State | 400001 | Nigeria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42041218 | Derived | Chijioke CP, Okafor MT, Nubila NI, Onah IC, Chijioke UO, Chigbo NN, Maduka IC, Udoh IP, Eleazar CI, Gbenimachor NM, Mbadiwe NC, Nwadike KI, Anusiem CA, Nwosu NI, Okpe AC, Muobike AT, Nwokolo BA, Udorah MI, Nnadozie OJ, Nwonu PC, Ndiokwelu CI, Okwara CC, Oji LC, Okoli UA, Uamai IM, Anakwue RC, Amah CC, Ironkwe NF, Ekwe EA, Aniagor EN, Ayuk CO, Aneziokoro EA, Onwasigwe CN, Ugwoke U, Ide C, Effiong-Essien CR, Chima-Enema N, Onyia BU, Okwy-Nweke C, Enuka HC, Onwuka-Kalu N, Obiefuna A, Okpara TC, Maduabuchi JU, Okwara CC; (Dietary Intervention Research Group). Personalized Food Avoidance Dietary Approach for Psoriasis and Hypertension: A Case Study and Pilot Trial. Niger J Clin Pract. 2024 Oct 1;27(10):1202-1215. doi: 10.4103/njcp.njcp_152_24. Epub 2024 Oct 30. |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Other |
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